What is the brand name for denosumab?

Before receiving denosumab injection, you should know that denosumab injection is available under the brand names Prolia and Xgeva. You should not receive more than one product containing denosumab at the same time.

Who is the manufacturer of denosumab?

XGEVA® (denosumab) prescribing information, Amgen.

Does Amgen make Prolia?

FDA Approves Prolia® (Denosumab) For Glucocorticoid-Induced Osteoporosis| Amgen.

Is Zometa the same as denosumab?

Denosumab, a monoclonal antibody, is given as a subcutaneous injection and works by blocking a protein called RANK ligand, which tells the body to remove bone. Zometa, an intravenous bisphosphonate, uses a slightly different strategy—it attaches directly to the surface of bone to halt bone breakdown.

Are there any adverse events with denosumab or zoledronic acid?

Adverse events were recorded in 916 patients (97%) on denosumab and 918 patients (97%) on zoledronic acid, and serious adverse events were recorded in 594 patients (63%) on denosumab and 568 patients (60%) on zoledronic acid.

Is there a Phase 2 trial for denosumab?

Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. including for prevention of bone metastases.

What are the most common side effects of denosumab?

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Percentages noted with Prolia (60 mg every 6 months) or Xgeva (120 mg every 4 weeks). Cardiovascular: Peripheral edema (Prolia: 5%; Xgeva: 17%)

How is denosumab used to treat prostate cancer?

Soluble receptor activator of nuclear factor κB Fc diminishes prostate cancer progression in bone. Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. including for prevention of bone metastases.

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