What is the purpose of the protamine injection?

Protamine is a medication used to reverse and neutralize the anticoagulant effects of heparin. Protamine is the specific antagonist that neutralizes heparin-induced anticoagulation.

What happens if you give protamine too fast?

Administer protamine 10 mg/mL solution undiluted via slow intravenous injection. The administration rate MUST NOT exceed 50 mg over a 10 minute period. High doses and rapid administration may result in severe hypotension, cardiovascular collapse, pulmonary edema, pulmonary vasoconstriction, and pulmonary hypertension.

Does protamine reverse LMWH?

Protamine sulphate rapidly reverses unfractionated heparin (UFH) and partially reverses low molecular weight heparin (LMWH – about 60% reversal). Protamine can cause severe allergic reactions including anaphylaxis, hypertension, bronchospasm and skin reactions in up to 10% patients.

What is protamine sulfate an antidote for?

Protamine sulfate is used to reverse the anticoagulant effects of heparin following cardiovascular surgical procedures. Systemic hypotension is not uncommon following administration of this drug.

What do you need to know about protamine sulfate injection?

Protamine Sulfate Injection, USP is a sterile, isotonic solution of protamine sulfate. It acts as a heparin antagonist. It is also a weak anticoagulant. Each mL contains: Protamine sulfate 10 mg; sodium chloride 9 mg; Water for Injection q.s. Sulfuric acid and/or dibasic sodium phosphate (heptahydrate) may have been added for pH adjustment.

What kind of medications are used for bipolar disorder?

Other treatments may include antipsychotics or antidepressants. Medications should be combined with nonpharmacological treatments, such as: Cognitive-behavioral therapy: This looks into any negative thought patterns you may have and challenges them in order to change your behavior.

Is there a complete reversal of anti-Xa activity with protamine?

1,2 For both enoxaparin and dalteparin, protamine does not provide a complete reversal of anti-Xa activity. It is estimated that protamine will reverse up to about 60% to 75% of anti-Xa activity.1,2 Enoxaparin (Lovenox®) Enoxaparin reversal is determined based on the following table:1 Time Since Enoxaparin Dose Protamine Dose ≤ 8 hours

When to take protamine sulfate after cardiac surgery?

Hyperheparinemia or bleeding has been reported in experimental animals and in some patients 30 minutes to 18 hours after cardiac surgery (under cardiopulmonary bypass) in spite of complete neutralization of heparin by adequate doses of protamine sulfate at the end of the operation.