Is melphalan a vesicant or irritant?

Chemotherapy vesicant & irritant properties and suggested management for extravasation

Which of the following is an irritant with vesicant properties?

Drugs that are classified as irritants with vesicant properties include docetaxel, liposomal doxorubicin, melphalan, mitozantrone, oxaliplatin, paclitaxel and nab-paclitaxel.

Which is an irritant with a vesicant property?

This clinical procedure outlines the management of an extravasation with the following drugs that are known to be irritants with vesicant properties; docetaxel, liposomal doxorubicin, melphalan, mitozantrone, oxaliplatin, paclitaxel or nab paclitaxel.

Which is the best melphalan for older patients?

Melphalan 200 mg/m 2 is considered safe in older fit patients and melphalan 140 mg/m 2 has been shown to be as effective when a dose reduction is required. The performance status of a patient should be considered along with other parameters such as renal function and age when deciding on the dose of melphalan.

How to manage chemotherapy vesicant and irritant properties?

Chemotherapy vesicant & irritant properties and suggested management for extravasation. If cooling techniques are being used, withhold cooling 15 minutes before and after the infusion. Infuse in an extremity or area other than the one affected by extravasation. Reduce dose by 50% for patients with creatinine clearance <40 mL/min.

What is the difference between a flare reaction and a vesicant?

Definitions Extravasation: Leakage of a medication into tissue or extravascular space around the infusion site. Flare reaction: A skin reaction to a medication which is an allergic response. Vesicant: Medication that may causes severe and/or irreversible tissue injury and necrosis.