What is p16 antibody?

Anti-P16 antibodies are readily available from several suppliers. P16 is a reported synonym of the human protein ‘cyclin dependent kinase inhibitor 2A’, encoded by the gene CDKN2A. The full protein is reported to be 156 amino acid residues in length.

Is p16 a tumor suppressor?

p16Ink4a is a protein involved in regulation of the cell cycle. Currently, p16Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16Ink4a has also been described in several tumors.

What is Akt cell signaling?

Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including Bad (7), forkhead transcription factors (8), c-Raf (9), and caspase-9. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (10).

Is p16 positive bad?

Expression of p16INK4A (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinoma (HNSCC), however, p16-positivity is not limited to HPV positive tumors and therefore, not a perfect surrogate for HPV.

Is there a western blot for p16 INK4a?

Western blot analysis of extracts from HeLa and SK-N-MC cells, using p16 INK4A Antibody. Western blot analysis of extracts from HeLa and SK-N-MC cells, using p16 INK4A Antibody. Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Is there an antibody for p16 INK4a in rabbits?

Specificity / Sensitivity. p16 INK4A (D7C1M) Rabbit mAb recognizes endogenous levels of total p16 INK4A protein. This antibody does not cross-react with p15 INK4B. This antibody is not recommended for use in immunohistochemistry.

Which is the best antibody for inhibiting CDK4?

The inhibitors of CDK4 (INK4) family include p15 INK4B, p16 INK4A, p18 INK4C and p19 INK4D. p18 has been shown to function as a haploinsufficient tumor suppressor in vivo (2). All INK4 proteins are composed of 32 amino acid ankyrin motifs and selectively inhibit CDK4/6 activity.