How does cell proliferation relate to differentiation?

Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells continue division before acquiring a fully differentiated state, while terminal differentiation usually coincides with proliferation arrest and permanent exit from the division cycle.

How do you quantify cell proliferation?

Besides overall metabolic activity, cell proliferation may be measured by examining one or more specific markers within a cell. A well-published example is the BrdU incorporation assay. In this assay, cells are treated with BrdU, a thymidine analog that is incorporated into the DNA during cell proliferation.

What is cell proliferation?

An increase in the number of cells as a result of cell growth and cell division.

What are the three requirements of cell proliferation?

A number of environmental factors (internal environment) contribute to and regulate cell proliferation. This includes such factors as nutrients, temperature levels, pH, and oxygen among others.

Where does activation, proliferation and differentiation take place?

After export of B-cell from the bone-marrow, activation, proliferation and differentiation occur in the periphery and require antigen. Depending on the nature of the antigen, B cell activation proceeds by two different routes, one dependent of TH cell, the other not.

What is the definition of cell proliferation in biology?

Cell proliferation refers to the processes that result in an increase in the number of cells. As such, it’s a fundamental process among living organisms that is necessary for general development (embryonic development, organ growth, and development as well as various physiological processes).

What happens to a cell when it differentiates?

Differentiated cells have specific functions to fulfil. Once they differentiate, the rate of proliferation decreases. Furthermore, they lose the ability of cell differentiation. These cells remain in the G 0 stage of the cell cycle without proliferating. Cell differentiation is finely controlled by gene regulation.

Where does B cell proliferation and activation occur?

B-cell proliferation and activation: After export of B-cell from the bone-marrow, activation, proliferation and differentiation occur in the periphery and require antigen. Depending on the nature of the antigen, B cell activation proceeds by two different routes, one dependent of TH cell, the other not.