What is pulsatile drug delivery system?

Pulsatile drug delivery is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-released period, i.e., lag time, or these systems have a peculiar mechanism of delivering the drug rapidly and completely after a lag time, i.e., a period …

What is Pulse drug?

Pulse medication is an alternative programme to continuous medication for the control of disease. The medication is given either in water or feed for short periods of only 48-72 hours. Only medicines with short withdrawal periods can be used if pigs are near market weight.

What is Chronotherapeutic drug delivery system?

ChrDDs refers to a treatment method in which in vivo drug availability is timed to match circadian rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. Several techniques have been developed but not many dosage forms for all the diseases are available in the market.

Where does a Pulsatile Drug delivery system take place?

Pulsatile drug-delivery systems can be classified into site-specific systems in which the drug is released at the desired site within the intestinal tract (e.g., the colon), or time-controlled devices in which the drug is released after a well-defined time period.

Which is an example of an oral pulsatile delivery system?

In particular, oral pulsatile drug release pertains to the burst delivery of drugs following a programmed pattern from the time of oral administration. For example, Ritalin LA capsule is a pulsatile delivery system that provides IR of 50% of the total dose upon oral ingestion followed by a burst release of the remaining drug after 4 hours.

What is the release time of a pulsatile?

A pulsatile-release profile is characterized by a time period of no release (lag time) followed by a rapid and complete drug release.

How is pulsatile delivery different from continuous delivery?

Pulsatile delivery profoundly stimulates gonadotropin synthesis and secretion, whereas continuous delivery does not. GnRH pulses vary in their amplitude, frequency, and shape. Among these characteristics, frequency modulation appears to be most important for driving changes in reproductive state.