What are the different patterns of ANA?

The different ANA patterns are abbreviated as follows: Homogenous (H-ANA), Speckled (S-ANA), Nucleolar (N-ANA), Cytoplasmic (C-ANA), Centromere (Cen-ANA), Mitochondrial (M-ANA), and some mixed patterns such as Speckled + Cytoplasmic (SC-ANA), Homogenous + Mitochondrial (HM-ANA), Homogenous + Nucleolar (HN-ANA).

What do ANA patterns mean?

The pattern of the ANA test can give information about the type of autoimmune disease present and the appropriate treatment program. A homogenous (diffuse) pattern appears as total nuclear fluorescence and is common in people with systemic lupus.

What is speckled pattern in ANA test?

Speckled: Fine and coarse speckles of ANA staining are seen throughout the nucleus. This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjögren’s syndrome, Systemic Sclerosis, Polymyositis, and Rheumatoid Arthritis.

What do you need to know about Ana screen?

ANA Screen,IFA, with Reflex to Titer and Pattern – Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren’s syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE.

What do the patterns on a positive ANA mean?

When the lab tech was looking at the fluoresceinated antibodies, it basically literally looked speckled. There are many other kinds of patterns: homogenous, centromere, nucleolar, speckled, rim etc. Each of these patterns possibly indicate the presence of specific nuclear antibodies.

Which is the competent level of ANA testing?

The group has defined six nuclear patterns as “Competent-Level”: homogeneous; speckled; dense fine speckled (DFS); centromere; discrete nuclear dots; and nucleolar. ICAP recommends that any laboratory performing ANA by IIF should be able to accurately and reproducibly identify these patterns.

How is a blood sample taken for an ANA test?

For an ANA test, a member of your health care team takes a sample of blood by inserting a needle into a vein in your arm. The blood sample is sent to a lab for analysis. You can return to your usual activities immediately.