What causes blaschko?

The cause of the distribution pattern is unknown. It is possibly a form of human ‘mosaicism’ where certain specific cells or groups of cells react differently from other cells due to chromosomal abnormalities. The embryological explanation of Blaschko’s lines is not at all clear.

Are blaschko lines real?

Blaschko’s lines, also called the lines of Blaschko, named after German dermatologist Alfred Blaschko, are lines of normal cell development in the skin. These lines are invisible under normal conditions. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns.

What are the features of Blaschko’s skin lesions?

In severe cases, all areas of the body are involved The most prominent cutaneous features are reddish or red‐yellow cribriform atrophic skin lesions. Areas of hyperpigmentation or hypopigmentation, along with telangiectases, are common in atrophic sites.

What causes a person to have hyperpigmentation in their skin?

Melanin is a pigment that gives skin its color. It’s produced by skin cells called melanocytes. Several different conditions or factors can alter the production of melanin in your body. Certain medications can cause hyperpigmentation. Also, some chemotherapy drugs can cause hyperpigmentation as a side effect.

Is there a natural history of hyperpigmentation in SPD?

Extensive cases can be variably associated with chromosomal anomalies. The natural history of SPD has not been reported, but persistence of the hyperpigmentation is expected. A rare biopsy done on a patient with hyperpigmented SPD showed increase melanin in the basal layer, similar to CALM. 12

How is Hydroquinone used to treat hyperpigmentation of the skin?

Topical prescription medication can treat some cases of hyperpigmentation. This medication usually contains hydroquinone, which lightens the skin. However, prolonged use of topical hydroquinone (without any breaks in use) can cause darkening of the skin, known as ochronosis.