What are Notch target genes?

Primary Notch target genes include two families of transcriptional factors Hes, including HES1 and HES5 as well as Hey including HEY1 and HEY2. Other Notch target genes include CCND1, CDKN1A, GATA3 and PTCRA. CNTN1 acts as a functional ligand of Notch.

What is the outcome of Notch signaling?

Notch signaling can control the patterns of gene expression within a cell by either upregulating or downregulating various genes. These alterations of gene expression can either induce or impair differentiation.

Which is the target gene of the Notch signaling pathway?

The Notch signaling pathway: transcriptional regulation at Notch target genes The Notch gene encodes a transmembrane receptor that gave the name to the evolutionary highly conserved Notch signaling cascade.

Why is Notch signaling a promising drug target?

Targeting Notch signaling is therefore a promising strategy for developing future therapies for the treatment of GBM. In this review we give an overview of the mechanisms of Notch signaling, its networking pathways in gliomas, and discuss its potential for designing novel therapeutic approaches. Gliomas are defined as brain tumors of glial origin.

What is the role of notch in the signaling cascade?

The Notch gene encodes a transmembrane receptor that gave the name to the evolutionary highly conserved Notch signaling cascade. It plays a pivotal role in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adul …

How does the Notch signaling pathway affect zebrafish?

Mutations in elements of the Notch signaling pathway affect the earliest intestinal cell fate decisions during zebrafish development. Transcriptional analysis and gain of function experiments revealed that Notch signaling targets Hes1 in the intestine and regulates a binary cell fate decision between adsorptive and secretory cell fates.