What is comedo necrosis in breast cancer?

High-grade DCIS is sometimes described as “comedo” or “comedo necrosis.” Comedo refers to areas of dead (necrotic) cancer cells, which build up inside the tumor. When cancer cells grow quickly, some cells don’t get enough nourishment. These starved cells can die off, leaving areas of necrosis.

What does invasive ductal carcinoma grade 3 mean?

Grade 3 cells, also called “poorly differentiated,” are more abnormal in their behavior and appearance. Surgical margins: When cancer cells are removed from the breast, the surgeon tries to take out the whole cancer with an extra area or “margin” of normal tissue around it.

What is intraductal carcinoma?

A noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other tissues in the breast. In some cases, intraductal breast carcinoma may become invasive cancer and spread to other tissues.

What is comedo type ductal carcinoma in situ?

Comedo type ductal carcinoma in situ. Casting-type microcalcifications are the most frequent mammographic finding (78% of cases) in comedotype DCIS. Histologically DCIS-comedo is diagnosed when at least one duct in the breast is filled and expanded by large, markedly atypical cells. It has the risk of occult infiltration. A comedo…

How is comedo carcinoma different from conventional DCIS?

There are some biological differences between conventional DCIS and comedo breast carcinoma in situ. For one thing, comedo carcinomas have a different expression pattern of tenascin, which is a large extra cellular matrix protein.

Is the comedo carcinoma of the breast invasive?

It is a fast growing type of breast cancer with some risk of future invasive cancer status, but most of the time comedo breast carcinoma is considered to be ‘ intraductal ‘, meaning, that it will be confined to the breast ducts.

What happens to the cells in a comedo carcinoma?

What typically happens in a breast comedo carcinoma is that some of the cells die off and form small groups. ( These small groups of dead cells are termed ‘comedo necrosis‘ ).

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