What is myocyte vacuolization?

Myocyte vacuolization, possibly indicating ischemic injury, is common in biopsies from cardiac transplant patients and is associated with abnormal acetylcholine response in large epicardial arteries.

What does Myocytolysis mean?

Myocytolysis refers to a state of significant damage to cardiac myocytes, muscle cells of the heart, caused by myocardial strain.

What does cytoplasmic vacuolization mean?

Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds.

What is cell vacuolization?

Vacuolization is the formation of vacuoles or vacuole-like structures, within or adjacent to cells. In dermatopathology “vacuolization” often refers specifically to vacuoles in the basal cell-basement membrane zone area, where it is an unspecific sign of disease.

What is Subendocardial Vacuolization?

Focal or diffuse subendocardial vacuolization of myocytes, or myocytolysis, may be a marker for reversible ischemic injury. Myocytolysis is a clearing of the sarcoplasm and nuclei, with nuclear enlargement and prominent nucleoli.

Is a muscle a cell?

Skeletal muscle fibers are made when myoblasts fuse together; muscle fibers therefore are cells with multiple nuclei, known as myonuclei, with each cell nucleus originating from a single myoblast.

What is contraction band necrosis?

Contraction band necrosis is a type of uncontrolled cell death (necrosis) unique to cardiac myocytes and thought to arise in reperfusion from hypercontraction, which results in sarcolemmal rupture. It is a characteristic histologic finding of a recent myocardial infarction (heart attack) that was partially reperfused.

What does Vacuolated mean?

Medical Definition of vacuolated : containing one or more vacuoles vacuolated cells.

What causes Blebbing?

Blebs are protrusions of the cell membrane. They are the result of actomyosin contractions of the cortex, which cause either transient detachment of the cell membrane from the actin cortex or a rupture in the actin cortex. Then, cytosol streams out of the cell body and inflates the newly formed bleb.

What is growth in a cell?

Cell growth refers to the increase in cell size (mass accumulation) while cell division describes the division of a mother cell into two daughter cells (1->2->4->8, etc.). Cell proliferation is the process of generating an increased number of cells through cell division.

What is the medical definition of vacuolization?

“Vacuolization.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/vacuolization. Accessed 9 Jun. 2021. Love words? Need even more definitions? Subscribe to America’s largest dictionary and get thousands more definitions and advanced search—ad free!

What kind of Vacuoles do cardiac myocytes have?

Some of the cardiac myocytes have variably sized vacuoles (arrows). ) is considered to be a degenerative process, consisting of multifocal or widespread accumulation of multiple, welldemarcated, round, variably sized (primarily small), clear vacuoles.

How to diagnose vacuolation in cardiomyocytes?

In other cases, vacuolation forms from distension of the sarcoplasmic reticulum within cardiomyocytes. Electron microscopic examination may be used to positively identify the source and content of the vacuoles. Cytoplasmic vacuolation of the cardiomyocytes should be diagnosed whenever present. It should be graded based on the extent of the lesion.

What does vacuolization of epidermal keratinocytes mean?

Perinuclear vacuolization of epidermal keratinocytes is most likely inconsequential when not observed in combination with other pathologic findings. In dermatopathology “vacuolization” often refers specifically to vacuoles in the basal cell-basement membrane zone area, where it is an unspecific sign of disease.