What is meant by organic synthesis?

Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory.

What is a synthetic route?

In a similar way, when a chemist working in the lab embarks upon the synthesis of a compound, he or she follows a “synthetic route”— a series of steps by which a chemical compound is assembled from smaller, less complex bulk chemicals. These promise to put CAOS in the hands of the lab-based chemist.

What is synthesis of a drug?

Chemical synthesis is the skill set at the heart of discovering new drug molecules. The pharmaceutical industry employs thousands of chemists who craft compounds by a complex and carefully planned step-by-step synthetic process—making original molecules from available precursors.

How do you create a synthetic route?

In order to plan a synthesis route, the chemist must first look at the required compound (the target compound). By looking at the functional groups on the target compound, the chemist can work backwards, through a logical sequence of reactions until the suitable starting materials can be found.

What is synthesis Example?

It’s simply a matter of making connections or putting things together. We synthesize information naturally to help others see the connections between things. For example, when you report to a friend the things that several other friends have said about a song or movie, you are engaging in synthesis.

How does organic synthesis help in drug discovery?

Organic synthesis provides opportunities to transform drug discovery Despite decades of ground-breaking research in academia, organic synthesis is still a rate-limiting factor in drug-discovery projects.

Which is the best example of organic synthesis?

The US Food and Drug Administration approved in late 2010 a new drug for treatment of metastatic breast cancers ( 25 ). Eribulin’s structural complexity is unrivaled for a completely synthetic drug, and its discovery and large-scale manufacturing represent a landmark for the field of organic synthesis ( Fig. 1 ).

How did eribulin contribute to the field of organic synthesis?

Eribulin’s structural complexity is unrivaled for a completely synthetic drug, and its discovery and large-scale manufacturing represent a landmark for the field of organic synthesis ( Fig. 1 ). The inspiration for eribulin comes from an even more complex natural product, halichondrin B, which was isolated from a marine sponge.

Why do we need new reactions in organic synthesis?

There is also a need for new reactions that enable non-traditional disconnections, more C-H bond activation and late-stage functionalization, as well as stereoselectively substituted aliphatic heterocyclic ring synthesis, C-X or C-C bond formation.