What is roflumilast indication?

INDICATION. Roflumilast is indicated as a treatment to reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. This medication is not a bronchodilator, and it is not indicated for the treatment of acute bronchospasm.

What are some of the side effects of roflumilast?

Roflumilast may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• diarrhea.
• nausea.
• dizziness.
• headache.
• back pain.
• muscle spasm.
• decrease in appetite.
• uncontrollable shaking of a part of your body.

Does roflumilast cause depression?

1,4 Depression, anxiety, and insomnia occur about twice as often in patients taking roflumilast as in those taking placebo.

What makes roflumilast special?

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system.

What is another name for roflumilast?

Roflumilast, sold under the trade name Daxas among others, is a drug that acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4).

What is the brand name for roflumilast?

DALIRESP® (roflumilast) – For Adults with Severe COPD.

What time of day should you take daliresp?

Your doctor has determined which dose is appropriate for you to start on. DALIRESP is taken once daily, with or without food. If your doctor started you on the 250-mcg dose, you should take it once daily for the first 4 weeks only. After the first 4 weeks, you will increase to the 500-mcg dose.

What does daliresp do to lungs?

It works by selectively inhibiting phosphodiesterase 4 (PDE4), an enzyme previously linked to COPD progression. While animal studies suggest that Daliresp may also reduce inflammation in the lungs, few studies have investigated its anti-inflammatory potential in humans.

Is daliresp a corticosteroid?

DALIRESP is the only medicine of its kind for COPD and works differently from steroids. It belongs to a group of medications called PDE4 (phosphodiesterase-4) inhibitors.

What is the generic for daliresp?

Roflumilast, the generic form of Daliresp has been approved by the Food and Drug Administration (FDA) and may be made available soon, making this COPD medication more affordable. Here are four things to know about roflumilast, the generic for Daliresp.

What is another name for DALIRESP?

Daliresp (roflumilast) is a selective phosphodiesterase 4 (PDE4) inhibitor indicated as a treatment for chronic obstructive pulmonary disease (COPD) in patients who also suffer from chronic bronchitis.

What time of day should you take DALIRESP?

Can a patient with renal impairment take roflumilast?

In patients with severe renal impairment, roflumilast and N-oxide metabolite AUCs were decreased by 21% and 7%, respectively, and C max was reduced 16% and 12%, respectively.

What are the contraindications for roflumilast in Canada?

Moderate to severe hepatic impairment (Child-Pugh class B or C). Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to roflumilast or any component of the formulation.

Is it safe to take rifampin with roflumilast?

RifAMPin: May decrease the serum concentration of Roflumilast. Management: Roflumilast U.S. prescribing information recommends against combining rifampin with roflumilast. The Canadian product monograph makes no such recommendation but notes that rifampin may reduce roflumilast therapeutic effects.

Are there any drug interactions with roflumilast or riociguat?

Drug Interactions. Riociguat: Roflumilast may enhance the hypotensive effect of Riociguat. Management: Riociguat is contraindicated with nonselective phosphodiesterase (PDE) inhibitors and PDE type 5 inhibitors. Other types of PDE inhibitors are not contraindicated, but caution is advised and patients should be monitored for hypotension.

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