What is the classification of donepezil hydrochloride?

Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities) by increasing the amount of a certain naturally occurring substance in the brain.

How is donepezil synthesized?

As reported in literature(14-16) the synthesis of donepezil is based on the aldol condensation/dehydratation between the indanone and the piperidine moieties, leading to an unsaturated precursor (Figure 1) that gives rise to donepezil after asymmetric hydrogenation.

Is donepezil a carbamate?

​4) (sold under the trade name Exelon) is a powerful, slow-reversible carbamate inhibitor that blocks cholinesterase activity through binding at the esteratic part of the active site. Unlike donepezil that selectively inhibits AChE, rivastigmine inhibits both BuChE and AChE.

What is donepezil mechanism?

Mechanism of Action Donepezil binds reversibly to acetylcholinesterase and inhibits the hydrolysis of acetylcholine, thus increasing the availability of acetylcholine at the synapses, enhancing cholinergic transmission.

Is donepezil worth taking?

Donepezil is more effective than placebo and is well tolerated in improving the major symptoms of this disease. Improvements are usually modest, although stabilization of cognitive and functional symptoms with donepezil can also be considered an important clinical outcome. Donepezil may lessen caregiver burden.

Is donepezil neuroprotective?

Donepezil, an anti-Alzheimer’s disease drug has the neuroprotective effect on RGCs derived from familial glaucoma patients’ iPS cells. You are adding an alert for: Donepezil, an anti-Alzheimer’s disease drug has the neuroprotective effect on RGCs derived from familial glaucoma patients’ iPS cells.

What is galantamine made from?

First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sources, such as Galanthus nivalis. Galantamine was first studied in paralytic and neuropathic conditions, such as myopathies and postpolio paralytic conditions, and for reversal of neuromuscular blockade.

How good is donepezil?

There is strong evidence that donepezil has efficacy against the three major domains of Alzheimer’s disease symptoms, namely functional ability, behavior, and cognition. The strongest evidence is for improvement or less deterioration in global outcomes and cognition in the short to medium term.

How does donepezil help dementia?

Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine. This means there is a higher concentration of acetylcholine in the brain, which leads to better communication between nerve cells. This may ease some symptoms of Alzheimer’s disease for a while.

What is the process for preparation of donepezil hydrochloride?

WO2012131540A1 – A process for preparation of intermediates of donepezil hydrochloride – Google Patents The present invention provides a process for the preparation of key intermediate for the synthesis 5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1-indanone hydrochloride (donepezil hydrochloride).

Is the drug donepezil a reversible inhibitor of acetylcholinesterase?

Donepezil hydrochloride, a piperidine derivative, is a centrally active, reversible inhibitor of acetylcholinesterase. The drug is structurally unrelated to other anticholinesterase agents (eg, tacrine, physostigmine).

What’s the maximum dose of donepezil you can take?

Mild to moderate disease: Maximum 10 mg daily. Moderate to severe disease: Maximum 23 mg daily. Maximum dosage of the fixed-combination preparation containing memantine and donepezil: 28 mg memantine hydrochloride and 10 mg donepezil hydrochloride once daily.

Are there any CYP3A inducers for donepezil?

CYP3A inducers: Possible increased metabolism of donepezil. Pharmacokinetic interactions unlikely with highly protein-bound drugs. Relative oral bioavailability is 100%. Orally disintegrating and conventional film-coated tablets are bioequivalent.