How do you reconstitute meropenem injection?

For intravenous infusion, meropenem vials may be directly reconstituted with 0.9 % sodium chloride or 5% glucose solutions for infusion. Each vial is for single use only. Standard aseptic techniques should be used for solution preparation and administration. The solution should be shaken before use.

Why is meropenem injection given?

Meropenem injection is used to treat skin and abdominal (stomach area) infections caused by bacteria and meningitis (infection of the membranes that surround the brain and spinal cord) in adults and children 3 months of age and older. Meropenem injection is in a class of medications called antibiotics.

Can meropenem be reconstituted with normal saline?

The mean meropenem concentrations reconstituted in normal saline solution decreased 1.66%, 3.31% and 5.80% after 2, 4 and 8 hours storage at 20 degrees C, respectively.

Why is meropenem given over 3 hours?

Conclusions: Compared with conventional regime of 30-minute infusion of meropenem in the treatment of HAP in ICU patients, the clinical efficacy can be improved, the severity of the disease can be reduced, the recovery of organ failure and long-term prognosis can be improved with 3 hour extended infusion of meropenem.

How long should meropenem be given?

Clinical practice guidelines recommend meropenem for 4 to 7 days for severe or high-risk community-acquired infections or complicated health-care associated infections. 20 mg/kg/dose IV every 8 hours (Max: 1 g/dose).

What is the action of meropenem?

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.

Is meropenem strong?

Frequently asked questions about meropenem (Merrem) Meropenem (Merrem) is considered one of the stronger antibiotics. It works against many types of bacteria and treats severe or complicated infections when other antibiotics may not be enough. Keep in mind that “stronger” antibiotics are not always the best choice.

What are side effects of meropenem injection?

SIDE EFFECTS: Swelling, redness, pain, or soreness at the injection site may occur. This medication may also infrequently cause upset stomach, headache, nausea, vomiting, constipation, or diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Can meropenem be given IV push?

Meropenem is usually given by intravenous infusion over approximately 15 to 30 minutes (see section 6.2, 6.3 and 6.6). Alternatively, doses up to 1 g can be given as an intravenous bolus injection over approximately 5 minutes.

How many days should meropenem be given?

How fast do you run meropenem?

How many mg of meropenem do I need for injection?

There is inadequate information regarding the use of meropenem for injection in patients on hemodialysis or peritoneal dialysis. Meropenem for Injection USP and Sodium Chloride Injection USP in the DUPLEX® Container is designed to deliver a 500 mg or 1 gram dose of meropenem.

How to dissolve 500 mg meropenem in sterile water?

Re-constitute injection vials (500 mg and 1 gram) with sterile Water for Injection (see table 4 below). Shake to dissolve and let stand until clear. 500 mg Meropenem for Injection USP and 50 mL Sodium Chloride Injection 0.9% USP in DUPLEX® Container

What do you need to know about Merrem injection?

(meropenem) for Injection, for Intravenous Use DESCRIPTION MERREM®IV (meropenem for injection) is a sterile, pyrogen-free, synthetic, carbapenem antibacterialfor intravenous administration.

What is meropenem used for in the United States?

Meropenem for Injection USP and Sodium Chloride Injection USP is indicated for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species.