What is dexmedetomidine HCl used for?

What Is Precedex? Precedex (dexmedetomidine hydrochloride) is an alpha2-adrenergic agonist with sedative properties used for short-term intravenous sedation.

How do you mix dexmedetomidine?

To prepare the infusion, withdraw 2 mL of Precedex Injection Concentrate, and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.

Is dexmedetomidine compatible with dextrose?

Precedex has been shown to be compatible when administered with the following intravenous fluids: 0.9% sodium chloride in water. 5% dextrose in water.

How is dexmedetomidine administered?

IM injection (2.5 mcg/kg) of dexmedetomidine has been used for premedication. Dexmedetomidine Hydrochloride injections are available as Dexmedetomidine 50mcg/0.5ml, 100mcg/ml and 200mcg/2ml. It should be used in controlled intravenous device when being used via intravenous route.

What type of drug is dexmedetomidine?

Dexmedetomidine is a new generation highly selective α2-adrenergic receptor (α2-AR) agonist that is associated with sedative and analgesic sparing effects, reduced delirium and agitation, perioperative sympatholysis, cardiovascular stabilizing effects, and preservation of respiratory function.

Can nurses give precedex?

Because many drugs are excreted in human milk, caution should be exercised when Precedex is administered to a nursing woman. There have been no clinical studies to establish the safety and efficacy of Precedex in pediatric patients below 18 years of age. Therefore, Precedex should not be used in this population.

Why is precedex limited to 24 hours?

The FDA states that if used for >24 hours, dexmedetomidine can cause tolerance and tachyphylaxis. The FDA also states that prolonged exposure can cause a dose-related increase in adverse events such as acute respiratory distress syndrome (ARDS), respiratory failure and agitation.

Is precedex better than propofol?

Conclusions: For ICU patient sedation, dexmedetomidine may offer advantages over propofol in terms of decrease in the length of ICU stay and the risk of delirium. However, transient hypertension may occur when dexmedetomidine is administered with a loading dose or at high infusion rates.

What is the difference between Medetomidine and dexmedetomidine?

Medetomidine is faster acting and more effective than dexmedetomidine following IM administration in dogs. Medetomidine may induce less vasoconstriction at injection site, faster uptake and more rapid onset of action.

What is the antidote for precedex?

The intravenous administration of anticholinergic agents (e.g., glycopyrrolate, atropine) should be considered to modify vagal tone. In clinical trials, glycopyrrolate or atropine were effective in the treatment of most episodes of Precedex-induced bradycardia.

When was Dexmedetomidine hydrochloride injection first approved?

Precedex (dexmedetomidine hydrochloride) Injection Precedex (dexmedetomidine hydrochloride) Injection, Concentrate For intravenous infusion of injection following dilution of concentrate Initial U.S. Approval: 1999.

When to use Dexmedetomidine hydrochloride for sedation?

Dexmedetomidine Hydrochloride Injection is a central alpha-2 adrenergic agonist indicated for sedation of non-intubated patients prior to and/or during surgical and other procedures. (1) ———————-DOSAGE AND ADMINISTRATION———————–

What is the molecular weight of dexmedetomidine HCl?

Dexmedetomidine has a molecular weight of 236.7 and the empirical formula is C13H16N2• HCl and the structural formula is: Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1. Its partition coefficient in-octanol: water at pH 7.4 is 2.89.

How much dexmedetomidine is in 1 mL of Precedex?

Its partition coefficient in-octanol: water at pH 7.4 is 2.89. Precedex is supplied as a clear, colorless, isotonic solution with a pH of 4.5 to 7.0. Each 1 mL of Precedex contains 118 mcg of dexmedetomidine HCl (equivalent to 100 mcg dexmedetomidine base) and 9 mg of sodium chloride in water.