Can NSAIDs cause terminal ileitis?

Non-steroidal anti-inflammatory drug (NSAID) intake as well as other pathological conditions such as lymphoid hyperplasia, intestinal infections, lymphoma, infections and ulcerative colitis (UC) can mimic CD terminal ileitis.

How does NSAID cause gastric ulcers?

By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. Some NSAIDs have less effect on prostaglandins in the stomach than others, and, therefore, may have a lower risk of causing ulcers, but the increased risk of ulcers still exists.

Can NSAIDs cause colon ulcers?

NSAID causes direct mucosal injury by many mechanisms including interfering with the protective effect of prostaglandins. They are reported to cause erosions, ulcers, hemorrhage, perforations, strictures and the complications of diverticulosis, in the small and large intestine.

Which NSAIDs cause ulcers?

Most peptic ulcers are caused by infection with the bacterium Helicobacter pylori (H. pylori). But some peptic ulcers are caused by prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve).

How long does it take for an NSAID ulcer to heal?

NSAID-related ulcers heal in most patients within two to three months when they are treated with H2-receptor antagonists with or without antacid, omeprazole, or misoprostol.

Do NSAIDs cause ischemic colitis?

NSAIDs are well known for causing inflammation and ulcerative disease of the upper gastrointestinal tract. These drugs can also cause injury to the distal small bowel and colon which can resemble symptoms of inflammatory bowel disease, ischemic colitis, infectious colitis and diverticulitis.

What should I do if I have an NSAID induced ulcer?

NSAID-induced ulcers usually heal once the NSAID is stopped. Treatment may be recommended to speed up the healing process. In other cases, surgery may be needed. A physician may recommend taking one or more medications. Over-the-counter options include:

What are the treatment options for ileocolonic anastomotic ulcers?

The commonest presentation is with iron deficiency anemia due to occult blood loss. The etiology of the ulcer, in most patients, remains speculative. The therapeutic approach to these ulcers is to discontinue all NSAIDs, treat underlying inflammatory bowel disease, if present, and supplement with oral iron.

Is the distal small bowel susceptible to NSAIDs?

The distal small bowel and colon are susceptible to the deleterious effects of nonsteroidal anti-inflammatory drugs (NSAIDs) [ 1-5 ]. The ileocecal region is a potential site for a variety of NSAID-induced injuries including erosions, ulcers, strictures, perforation, and the formation of diaphragms, which can lead to bowel obstruction [ 4-7 ].

What happens when you have your ileum removed?

Surgical removal of the ileum is also called small bowel resection. The most common reasons for the surgery may be: Uncontrolled bleeding due to perforated ulcers or injury. Blockage of the ileum due to tumors or scar tissue.