How is cyclophosphamide administered?

It is usually given through a vein by injection or infusion (intravenous, IV) or by mouth in tablet form, depending upon diagnosis. Cyclophosphamide is also approved to be given by a shot into a muscle (IM), into the abdominal lining (intraperitoneal, IP), or into the lining of the lung (intrapleural).

What instructions should be given to a patient taking cyclophosphamide?

Take cyclophosphamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow the tablets whole; do not split, chew, or crush them.

How do you administer cyclophosphamide IV?

If the solution is to be used for IV infusion, Cyclophosphamide (containing cyclophosphamide) is reconstituted by adding sterile water for injection or 0.9% sterile sodium chloride solution. Reconstituted Cyclophosphamide should be further diluted in 5% dextrose or 0.9% sodium chloride solution prior to infusion.

What should I monitor with cyclophosphamide?

Your doctor will order regular lab tests to check your response to cyclophosphamide and monitor for toxicity. Your blood counts – white blood cells, red blood cells and platelets – will be checked regularly. Your liver enzymes and urine will be checked regularly as well.

Is cyclophosphamide a strong chemo drug?

Cyclophosphamide, also called Cytoxan, is classified as a “cytotoxic agent”, because it has a toxic effect on many types of cells (“good” cells as well as “bad”). Cyclophosphamide is one of a number of medications first developed as a chemotherapy drug (a medication used in the treatment of cancer).

How long does cyclophosphamide take to work?

How long will cyclophosphamide take to work? Cyclophosphamide does not work immediately. It may take 6 weeks or more to produce an effect.

How fast does cyclophosphamide work?

How long does it take for cyclophosphamide to work?

How fast can you infuse cyclophosphamide?

infusions may be administered over 1 to 24 hours. Doses >500 mg to approximately 2 grams may be administered over 20- 30 minutes.

How long is cyclophosphamide in your system?

When cyclophosphamide is given intravenously, the white blood cell count tends to reach its low point (“nadir”) between 7 and 14 days after administration.

What is the side effect of cyclophosphamide?

Nausea, vomiting, loss of appetite, stomach ache, diarrhea, or darkening of the skin/nails may occur. Nausea and vomiting can be severe. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting.

When is the best time to take cyclophosphamide?

Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better.

When to send FBC for cyclophosphamide infusion?

• Ensure a full blood count is available from within the last 4 days (weeks 0, 2 and 4) or last 7 days (all other weeks) prior to infusion. If not available, FBC must be sent urgently and results reviewed prior to start of Cyclophosphamide. If WBC < 4 9×10 /L or Neutrophils < 2 x10 9 /L do not commence infusion. Inform Renal SpR or consultant.

How long to take cyclophosphamide for nephrotic syndrome?

Dosing for Minimal Change Nephrotic Syndrome in Pediatric Patients. An oral dose of 2 mg per kg daily for 8 to 12 weeks (maximum cumulative dose 168 mg per kg) is recommended. Treatment beyond 90 days increases the probability of sterility in males [see Use in Specific Populations (8.4)].

How often should I take a cyclophosphamide injection?

Recommended oral dose: 2 mg per kg daily for 8 to 12 weeks (maximum cumulative dose 168 mg per kg). Treatment beyond 90 days increases the probability of sterility in males. ———————DOSAGE FORMS AND STRENGTHS———————- Injection, lyophilized powder: 500 mg, 1 g, and 2 g (3) Tablet: 25 mg and 50 mg (3)

Who is prescribing cyclophosphamide in the United States?

Cyclophosphamide prescribing: Prescribing is restricted to Renal Consultants. Patients attending as a day case must have a day case admission on the Prescribing, Information & Communication System (PICS). Dosing: Age Creatinine <300 µmol/L Creatinine >300 µmol/L <60 15 mg/kg 12.5 mg/kg 60-70 12.5 mg/kg 10 mg/kg >70 10 mg/kg 7.5 mg/kg