Does indole-3-carbinol reduce estrogen?

Studies increasingly indicate that dietary indole-3-carbinol (I3C) prevents the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers. Epidemiological, laboratory, animal and translational studies support the efficacy of I3C.

Is indole-3-carbinol a phytoestrogen?

Indole-3-carbinol (I3C), a compound occurring naturally in cruciferous vegetables, exhibits a potent antitumor activity via its regulation of estrogen activity and metabolism. This study was designed to determine the effect of I3C on the potential to inhibit the ER-alpha.

What are the side effects of indole-3-carbinol?

Doses up to 400 mg daily have been used safely for 3-76 months. It can cause side effects such as skin rashes and diarrhea. In higher doses, indole-3-carbinol can cause balance problems, tremor, and nausea.

Does indole-3-carbinol increase testosterone?

According to our results, several steroid hormones (estradiol, estrone sulphate and androstenedione) were significantly increased in I3C treated tumor homogenates while testosterone was diminished. Interestingly, testosterone was significantly increased in the sera of I3C treated mice.

Does indole 3 carbinol really work?

There is some evidence that long-term use of indole-3-carbinol might reduce tumor (papilloma) growth in patients with recurrent respiratory papillomatosis. Laryngeal papillomatosis. Prevention of breast cancer.

Is it better to take DIM or I3C?

In summary, we have known for a long time that I3C is partially responsible for many of the beneficial effects of consuming cruciferous vegetables. I3C breaks down to many different active metabolites, but DIM appears to be the most stable, and the most measurable, making it easier to isolate.

Does DIM decrease estrogen?

DIM helps to eliminate active estrogen by promoting its conversion to the good estrogen metabolites.

What vegetable has the most indole-3-carbinol?

Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale.

Which is better DIM or I3C?

Why do bodybuilders take DIM?

DIM may allow estrogen metabolites in bodybuilding men to protect muscles from exercise-induced damage, resulting in less inflammation, less pain, and more rapid progress.

Which is better dim or I3C?

Does indole-3-carbinol really work?

Which is better indole 3 carbinol or estrogen?

Studies increasingly indicate that dietary indole-3-carbinol (I3C) prevents the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers. Epidemiological, laboratory, animal and translational studies support the efficacy of I3C. Whereas estrogen increases the growt …

How is indole 3 carbinol used to treat cancer?

DIM, a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone. Human reproductive cancers may be affected by estrogen levels, and Indole-3-Carbinol may prevent these by both reducing estrogen levels and blocking estrogen receptors.

How does indole 3 carbinol work with tamoxifen?

There is also evidence to support the fact that I3C has a different mechanism of action than tamoxifen and that these two substances can be used synergistically. Indole-3-Carbinol initiates a series of reactions in the body that culminates in the elimination of estrogen.

Is it safe to take indole 3 carbinol for testosterone?

Indole-3-carbinol may indirectly aid testosterone levels. Growing interest in indole-3-carbinol as a testosterone booster hinges mainly on its anti-estrogenic effects, which mostly sustain testosterone levels rather than elevate them.