What is proliferative breast lesion?

A group of noncancerous conditions marked by an increase in the growth of certain cells in the breast. Having one of these conditions may increase the risk of breast cancer. Examples include ductal hyperplasia, lobular hyperplasia, and papillomas.

What does atypia mean in the breast?

Atypical hyperplasia (or atypia) means that there are abnormal cells in breast tissue taken during a biopsy. (A biopsy means that tissue was removed from the body for examination in a laboratory.) These abnormal cell collections are benign (not cancer), but are high-risk for cancer.

What is proliferative breast disease without atypia?

Proliferative lesions without atypia (eg, intraductal papilloma, sclerosing adenosis, moderate hyperplasia of usual type) are associated with a 1.5- to 2-fold increased risk of breast cancer compared to nonproliferative lesions.

Can atypia turn into cancer?

Atypical hyperplasia isn’t cancer, but it increases the risk of breast cancer. Over the course of your lifetime, if the atypical hyperplasia cells accumulate in the milk ducts or lobules and become more abnormal, this can transition into noninvasive breast cancer (carcinoma in situ) or invasive breast cancer.

What is proliferative disease?

Abstract. A unifying concept that excessive proliferation of cells and turnover of cellular matrix contribute significantly to the pathogenesis of several diseases, including cancer, atherosclerosis, rheumatoid arthritis, psoriasis, idiopathic pulmonary fibrosis, scleroderma and cirrhosis of the liver, is presented.

What does epithelial proliferation mean?

An ‘epithelial proliferation’ means that epithelial cells (the kind of cell that usually comprise the lining of an organ) appear to be growing and accumulating more than normal.

What does atypia mean in medical terms?

Listen to pronunciation. (ay-TIH-pee-uh) State of being not typical or normal. In medicine, atypia is an abnormality in cells in tissue.

What is the treatment for atypical cells in breast?

Atypical hyperplasia is generally treated with surgery to remove the abnormal cells and to make sure no in situ or invasive cancer also is present in the area. Doctors often recommend more-intensive screening for breast cancer and medications to reduce your breast cancer risk.