What does asymmetric Dimethylarginine do?

Asymmetric dimethylarginine (ADMA), an analogue of L-arginine, is a naturally occurring product of metabolism found in human circulation. Elevated levels of ADMA inhibit NO synthesis and therefore impair endothelial function and thus promote atherosclerosis.

How do you reduce asymmetric Dimethylarginine?

Therapeutic measures to combat atherosclerosis may reverse these asymmetric dimethylarginine effects or at least reduce the concentration of this chemical in the blood. Such an effect can be achieved with competitor molecules or by increasing the expression or activity of its degradation enzyme.

What causes elevated ADMA?

Elevated levels of ADMA inhibit NO synthesis and therefore impair endothelial function and thus promote atherosclerosis. ADMA levels are increased in people with hypercholesterolemia, atherosclerosis, hypertension, chronic heart failure, diabetes mellitus and chronic renal failure.

What is meant by ADMA?

Infobox references. Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally essential amino acid.

How is high ADMA treated?

Focusing on the health of your endothelium may help to lower ADMA and SDMA levels. This may be accomplished through: Lifestyle changes, including a balanced diet that is low in fat and incorporates more fruits and vegetables. You should limit your intake of sweet and salty foods.

How do I lower my ADMA levels?

Therapies to lower ADMA/SDMA levels may include lifestyle changes to boost the health of the endothelium, such as weight loss, eating more fruits and vegetables, limiting or avoiding sugary and salty foods, regular exercise, and drug treatment to lower cholesterol and blood pressure if they are too high.

Why is arginine important?

L-arginine plays important roles in the metabolism of an organism. It is the precursor for the synthesis of proteins and other molecules of great biological importance, including nitric oxide, ornithine, polyamines, agmatine, proline, glutamate, creatine, dimethylarginine, and urea.

What does high ADMA mean?

Elevated ADMA is now widely recognized as a risk marker for vascular disease. Circulating concentrations of ADMA are increased in patients with renal failure, pulmonary hypertension, heart failure, hypercholesterolemia, and a range of other conditions associated with cardiovascular disease.

What is ADMA blood test?

The ADMA/SDMA biomarker blood test, now available through Cleveland HeartLab (CHL), measures levels of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Elevated levels of these biomarkers can signal damage to the endothelium, the inner lining of blood vessels.

What is high ADMA?

• Higher levels of ADMA are associated with a 1.40x increased. risk of CVD and coronary heart disease, as well as a 1.60x. increased risk of stroke, in a general population.2. • Elevated ADMA levels are associated with the presence of. hypertension,7 insulin resistance,7 and hyperlipidemia.8.