Can digoxin be given po?

PO (Adults): Digitalizing dose– 0.75–1.5 mg given as 50% of the dose initially and one quarter of the initial dose in each of 2 subsequent doses at 6–12 hr intervals. Maintenance dose– 0.125–0.5 mg/day depending on patient’s lean body weight, renal function, and serum level.

How will the intravenous administration be converted to oral administration?

Intravenous-to-oral (IV-to-PO [per oral]) switch therapy is a treatment procedure to convert the administration of medication from intravenous to oral. The procedure involves starting hospitalized patients on an initial intravenous therapy and stepping it down to oral therapy as early as possible.

Are oral and IV hydrocortisone equivalent?

What is the equivalent dose of oral prednisolone to intravenous (IV) hydrocortisone? Prednisolone 5mg orally is equivalent to hydrocortisone 20mg intravenously (equivalent anti-inflammatory dose).

Is keppra PO to IV conversion?

Replacement Therapy When switching from oral KEPPRA, the initial total daily intravenous dosage of KEPPRA should be equivalent to the total daily dosage and frequency of oral KEPPRA and should be administered as a 15-minute intravenous infusion following dilution in 100 mL of a compatible diluent.

Why is digoxin not used?

The use of digoxin is limited because the drug has a narrow therapeutic index and requires close monitoring. Digoxin can cause many adverse events, is involved in multiple drug interactions, and can result in toxicity. Despite its limitations, however, digoxin has a place in therapy.

When should you not take digoxin?

Tell your doctor straight away if you: have more than 2 of the common side effects – it means you could have too much digoxin in your blood. have a fast heart rate (palpitations), shortness of breath, feel dizzy or lightheaded and are sweating.

Why is intravenous better than oral?

Among physicians and patients alike, it is generally accepted that IV antibiotics are better than oral. They are stronger. They will work faster. They will save the day when oral antibiotics have failed.

Which route of administration is economically cheaper?

Among the various routes of administration of medications, oral administration is considered to be the most acceptable and economical method of administration.

Are oral and IV dexamethasone equivalent?

Rationale for dose conversion and choice of product Until now, clinical practice locally has used a conversion ratio of 1:1 when switching between oral and subcutaneous dexamethasone e.g. 4mg oral to 4mg sc. However, published studies show that the bioavailability of dexamethasone from oral tablets is highly variable.

Which is stronger hydrocortisone or prednisone?

Prednisone is 4 to 5 times more potent than hydrocortisone and has a longer duration of action, perhaps 12 hours or more. Dexamethasone is 40 to 50 times more potent than hydrocortisone and even longer-acting, 18 to 24 hours. Both of these glucocorticoids are given when a prolonged action is desired.

How fast can you give IV KEPPRA?

KEPPRA injection should be administered as a 15-minute IV infusion. One vial of KEPPRA injection contains 500 mg levetiracetam (500 mg/5 mL).

What should you not take with KEPPRA?

Common medications that may interact with Keppra include:

• antidepressants, such as SSRIs (eg, escitalopram, fluoxetine) and monoamine oxidase inhibitors, such as isocarboxazid, selegiline, or tranylcypromine.
• antiepileptics, such as carbamazepine and phenytoin.
• benzodiazepines, such as diazepam, oxazepam, and temazepam.

What’s the difference between IV and Po digoxin?

Drug Usual IV Dose* Approximate PO Dose* PO to IV Considerations/Comments Reference digoxin 0.1 -0.4 mg IV Q 24 H 0.125 -0.5 mg PO Q 24 H Oral bioavailability about 80% for tablets and liquid 1,2 dimenhyDRINATE 25-50 mg IV 25-50 mg PO Conversion of IV to PO is 1:1

What is the predicted CSS for digoxin injections?

Predicted Css= (Dose) (0.65 to 0.8)/ Digoxin clearance. Alternatively, maintenance dose= Loading dose x [0.14 x crcl / 500 ] Avoid IM injections-can lead to severe pain (If it must be given by this route, give deep IM followed by massage). Monitoring: Obtain blood samples at least 4 hours after IV dose and 6-8hours after oral dose.

How long does it take for a digoxin injection to work?

A single initial intravenous dose of 400 to 600 mcg (0.4 to 0.6 mg) of Digoxin Injection usually produces a detectable effect in 5 to 30 minutes that becomes maximal in 1 to 4 hours. Additional doses of 100 to 300 mcg (0.1 to 0.3 mg) may be given cautiously at 6- to 8-hour intervals until clinical evidence of an adequate effect is noted.

How much digoxin do I need for an intramuscular injection?

Intramuscular injection of digoxin is extremely painful and offers no advantages unless other routes of administration are contraindicated. Peak digoxin body stores of 8 to 12 mcg/kg should provide therapeutic effect with minimum risk of toxicity in most patients with heart failure and normal sinus rhythm.