What is a tPA catheter?

Catheter directed thrombolytic therapy is a nonsurgical treatment for acute deep vein thrombosis (DVT) that dissolves blood clots. These clots typically occur in your leg, thigh or pelvis but can travel.

What is intra-arterial tPA?

Intra-arterial thrombolysis is an option for treatment of selected patients who can be treated within 3-6 hours after the onset of symptoms due to occlusion of the middle cerebral artery and who are not otherwise candidates for IV tPA.

What is intra-arterial treatment?

Intra-arterial therapy (IAT) for acute ischemic stroke refers to endovascular catheter-based approaches to achieve recanalization using mechanical clot disruption, locally injected thrombolytic agents or both.

What is catheter directed thrombolysis?

Catheter-directed thrombolysis is a minimally invasive treatment that dissolves abnormal blood clots in blood vessels to help improve blood flow and prevent damage to tissues and organs.

How quickly does tPA work?

When administered quickly after stroke onset (within three hours, as approved by the FDA), tPA helps to restore blood flow to brain regions affected by a stroke, thereby limiting the risk of damage and functional impairment.

Can you surgically remove a blood clot?

Surgical thrombectomy is a type of surgery to remove a blood clot from inside an artery or vein. Normally, blood flows freely through your blood vessels, arteries, and veins. Your arteries carry blood with oxygen and nutrients to your body. Yours veins carry waste products back to the heart.

What is the maximum time from last known normal when intra-arterial thrombolysis?

For these patients, IAT may be considered as an alternative to IV thrombolysis, although currently IV tPA is the only validated approach and its use is recommended to a maximum of 4.5 h from stroke onset [10].

What is the maximum time from last known normal when intra-arterial thrombolysis can be performed?

The time from last seen normal to treatment with intravenous alteplase should be under 3 hours for eligible patients with the use of standard eligibility criteria.

Is blood clot surgery risky?

The risks of surgical thrombectomy include: Excess bleeding that can be severe enough to cause death. Infection. Damage to the blood vessel at the site of the blood clot.

What kind of catheter is used for tPA infusion?

Catheter for tPA infusion (must select one): EKOS catheter: Room temperature 0.9% NaCl to infuse via EKOS “Coolant Port” at 35 mL/hr Infuse tPA via “drug” port of EKOS catheter (not IV line) Infuse Heparin via side port EKOS catheter (if > 1 EKOS catheter in use, infuse heparin in only one catheter) Infusion Catheter:

When to use intra-arterial lytic therapy ( IAT )?

IAT is performed safely on patients after full dose IV t-PA. For patients with extracranial hemorrhage or a hemorrhagic tendency (e.g. recent surgery, anticoagulant use, etc) mechanical treatment alone is considered. Consideration for use of intra-arterial lytic therapy carries similar precautions to use of IV t-PA.

When to use IAT in addition to TPA?

IAT may be used in addition to intravenous tissue plasminogen activator (tPA) or in patients who do not qualify for tPA, usually because they are outside the approved 3-h timeframe window or have contraindications, such as elevated international normalized ratio or partial thromboplastin time.

How much Heparin is in a TPA infusion?

tPA and Heparin Infusion: q.o.d. tPA (alteplase) mg/250 mL 0.9% NaCl (0.04 mg/mL)10 Infuse at ______mg/hr (usual dose = 0.25 to 1 mg/hr, maximum dose = 2 mg/hr) Maximum total infusion dose = 40 mg (4 bags) Discontinue tPA if SBP > 210 or DBP > 120 and notify MD Heparin 25,000 units/250 mL D5W (100 units/mL) Record parameters on

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