What does it mean when GSTT1 is absent?

The GSTT1 null genotype may modulate the metabolism of exogenous pollutants or toxic intermediates. The absence of the GSTT1 enzyme, leading to genetic susceptibility toward certain pollutants, might determine the individual risk for development of acquired aplastic anemia in children.

What is GSTT1 gene?

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene. Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds.

What is GSTP1?

The GSTP1 gene is involved in a wide range of detoxification reactions which protect cells from carcinogens (3,4). GSTs provide protection against the electrophilic metabolites of carcinogens and reactive oxygen species. GSTP1 is a biotransformation enzyme expressed in normal breast epithelial cells.

What is GSTP1 I105V?

An aminoacid substitution (I105V) in GSTP1 produces a variant enzyme with lower activity and less capability of effective detoxification. This variant GSTP*B allele has been associated with a propensity to develop several neoplasms.

What is the function of the GSTM1 gene?

The GSTM1 gene encodes glutathione S-transferase M1, a member of the GST family of enzymes. These enzymes have broad detoxifying abilities against carcinogens, drugs, or other toxins.

How does GSTM1 play a role in detoxification?

Found this page useful? GSTM1 is a glutathione S-transferase (GST) which play a role in the detoxification of metabolites of environmental carcinogens including tobacco smoke. There is some evidence to suggest that people with common polymorphisms of these genes may have an increased susceptibility to a range of different cancers.

How is GSTM1 related to breast cancer risk?

Latest Publications: GSTM1 (cancer-related) When considered together, GSTM1 and GSTT1 genotypes were found to be associated with an increased risk of breast cancer. The relationship between GSTM1 and GSTT1 gene deletions and breast cancer risk was substantially altered by consumption of Smoked Meat/Vegetable.

What happens if you have fewer copies of GSTM1?

Individuals with fewer copies of GSTM1 may be somewhat more prone to allergies, asthma, and certain cancers, especially if they are missing copies of other GST family genes such as GSTP1 or GSTT1 .