What is ionotropic gelation?

Ionotropic gelation (IG) is a technique that allows the production of nanoparticles and microparticles by electrostatic interactions between two ionic species under certain conditions. At least one of the species has to be a polymer.

Which polymer forms microparticles by ionotropic gelation method?

Natural, biocompatible, and biodegradable polymers, such as chitosan, gelatin and alginate are commonly used in ionotropic gelation for biomedical applications [161]. The classical procedure involves electrostatic interaction between two ionic species of opposite charge to produce polymeric nano/microparticles.

What is emulsion gelation method?

The emulsion gelation technique, which encapsulates oil droplets within the hydrogels during crosslinking, was used to decrease their specific gravity in aqueous environments, resulting in floating drug release depots.

What are chitosan nanoparticles?

Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration.

What is sodium alginate?

Sodium Alginate (E401) is extracted from brown seaweed. It is used as a stabilizer for ice cream, yogurt, cream, and cheese. It acts as a thickener and emulsifier for salad, pudding, jam, tomato juice, and canned products. It is a hydration agent for noodles, bread, cool and frozen products.

Is chitosan a drug?

Chitosan is a sugar that is obtained from the hard outer skeleton of shellfish, including crab, lobster, and shrimp. It is used for medicine. Chitosan is used for high blood pressure, high cholesterol, obesity, wound healing, and other conditions, but there is little scientific evidence to support many of its uses.

Can we eat sodium alginate?

The study therefore indicates that the ingestion of sodium alginate at a high level for 23 days caused no effects other than those normally associated with a polysaccharide bulking agent; in particular, the enzymatic and other sensitive indicators of adverse toxicological effects remained unchanged.

What does sodium alginate do in food?

In the food industry, alginate is used as a thickening agent, gelling agent, emulsifier, stabilizer, texture-improver. Nowadays, alginate is added to numerous kinds of food, such as ice cream, jelly, acid milk drinks, dressings, instant noodles, beer, etc [6].

Is chitosan good for liver?

Chitosan, a natural product derived from chitin, possesses hypocholesterolemic properties similar to those of cholestyramine, but there has been no report concerning its effects on the equilibrium between dietary cholesterol and de novo cholesterol synthesis in the liver.

How is Ionotropic gelation based on polyelectrolytes?

Ionotropic gelation is based on the capability of polyelectrolytes to traverse link in the presence of counter ions to form nanoparticles (Giri et al., 2013d). In the ionic gelation method, chitosan polysaccharide is dissolved in aqueous acidic solution to get the cation of chitosan.

How is Ionotropic gelation used in Nanoarchitectonics?

T.K. Giri, in Nanoarchitectonics for Smart Delivery and Drug Targeting, 2016 Ionotropic gelation is based on the capability of polyelectrolytes to crosslink in the presence of counter ions (Giri et al., 2013d ). The ionic gelation method is most frequently used for the preparation of alginate nanoparticles.

How are hydrogel beads produced in Ionotropic gelation?

The hydrogel beads are produced by dropping a drug-loaded polymeric solution into the Ionotropic gelation is based on the ability of polyelectrolytes to aqueous solution of polyvalent cations.

How are CMC gels different from Ionotropic gelation?

CMC gels exhibited larger pores in the presence of CaCl 2. In polyelectrolyte complexation, CMS produced an increased agglomeration of particles, while the addition of CaCl 2 to AA generated dispersed particles of size in the order of millimeters.