What are E6 and E7 HPV?

ABSTRACT. The E6 and E7 genes of the high-risk human papillomavirus (HPV) types encode oncoproteins, and both act by interfering with the activity of cellular tumor suppressor proteins. E7 proteins act by associating with members of the retinoblastoma family, while E6 increases the turnover of p53.

What do E6 and E7 proteins do?

The HPV E6 and the E7 proteins modulate cellular proteins that regulate the cell cycle (reviewed in references 35 and 38). The E6 protein binds to the p53 tumor suppressor protein and targets it for accelerated ubiquitin-mediated degradation. The E6 protein also stimulates telomerase activity in cultured keratinocytes.

What does it mean if HPV mRNA E6 E7 is detected?

A “detected” result indicates the presence of high-risk HPV E6/E7 mRNA and is suggestive of an increased risk of cervical cancer.

Should I be worried about HPV E6 E7?

Data have shown that over-expression of E6 and E7 oncoproteins is a critical and necessary step toward HPV-related disease progression and cancer.

Is HPV mRNA E6 E7 high-risk?

The mRNA test determines the presence of E6/E7 mRNA from 14 high-risk HPV genotypes. HPV E6/E7 oncoproteins mediate the development of cervical cancer. Their overexpression, which can be measured as E6/E7 messenger RNA (mRNA) transcripts, is associated with a significantly increased risk of CIN and cervical cancer.

Can HPV E6 E7 go away?

It is important to know that the great majority of infections with high-risk HPV go away on their own (they are cleared by the immune system, usually within 2 years), and therefore do not lead to cancer. Infection with high-risk HPV may or may not cause symptoms.

Can HPV mRNA E6 E7 go away on its own?

It is important to know that the great majority of infections with high-risk HPV go away on their own (they are cleared by the immune system, usually within 2 years), and therefore do not lead to cancer.

What is the treatment for HPV E6 E7?

Treatment. There is no medical treatment for HPV infections, but the cervical lesions and warts that can result from HPV infections are treatable.

Is HPV E6 E7 low risk?

In contrast, low-risk HPV types, such as HPV-6 and HPV-11, which also infect genital epithelia, primarily induce benign lesions (16, 28, 55). In the high-risk HPV types, E6 and E7 have been shown to function as oncoproteins (18, 25).

Is HPV mRNA E6 E7 high risk?

Is HPV E6 E7 contagious?

Facts and definition of HPV HPV is highly contagious and is spread through close contact, including sexual contact. It is estimated that most sexually active people will become infected with HPV at some point. HPV infection typically does not cause signs or symptoms.

Is HPV mRNA E6 E7 common?

The overall prevalence of HPV was 97%. HPV E6 and E7 transcripts were detected in 188 of 204 (92%) biopsy specimens, of which 181 contained one of the following HPV types: 16, 18, 31, 33, or 45. Consensus PCR and type-specific PCR detected HPV in 187 of 204 and 188 of 204 (92%) specimens, respectively.