What is the function of thrombospondin 2?

Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating cell-matrix interactions, has been implicated in tissue repair and foreign body responses. Here we show that TSP2 has regulatory function in the chronic inflammatory lesions of rheumatoid arthritis.

What is TSP2?

TSP-2 is a 150 kDa calcium-binding protein that regulates cellular interactions with extracellular matrix. TSP-2 is a potent inhibitor of tumor growth and angiogenesis. TSP-2 regulates collagen matrix formation by altering fibroblast behavior during development and in areas of tissue remodeling in the adult.

How does angiogenesis affect tumor growth?

Why is angiogenesis important in cancer? Angiogenesis plays a critical role in the growth of cancer because solid tumors need a blood supply if they are to grow beyond a few millimeters in size. Tumors can actually cause this blood supply to form by giving off chemical signals that stimulate angiogenesis.

What triggers angiogenesis?

The mechanism of blood vessel formation by angiogenesis is initiated by the spontaneous dividing of tumor cells due to a mutation. Angiogenic stimulators are then released by the tumor cells. These then travel to already established, nearby blood vessels and activates their endothelial cell receptors.

What is the function of angiogenesis?

Angiogenesis is the process by which new blood vessels form, allowing the delivery of oxygen and nutrients to the body’s tissues. It is a vital function, required for growth and development as well as the healing of wounds.

What foods stop angiogenesis?

For example, repeated tests have shown that an abundance of fruits, herbs, vegetables, and spices, such as berries, grapes, soybeans, garlic, and parsley, inhibit angiogenesis by over 60%.

What are anti angiogenic foods?

Anti-angiogenic food include vegetables such as purple potatoes, carrots and leeks. Bero explained to WLBT that her diet also included berries, walnuts, green tea and herbs, such as garlic.

What cell releases VEGF?

VEGF is produced by many cell types including tumor cells,2,3 macrophages,4 platelets,5 keratinocytes,6 and renal mesangial cells. The activities of VEGF are not limited to the vascular system; VEGF plays a role in normal physiological functions such as bone formation,8 hematopoiesis,9 wound healing,10 and development.

What is the size of the THBS2 gene?

The THBS2 gene is 38,261 bases in size and is composed of 23 exons. Exons 3-22 encode the 5,808 base mRNA. Transcription Unlike TSP1, TSP2 is less-to-moderately responsive to serum in mouse NIH3T3 and Swiss 3T3 cells respectively. Transcription of THBS2 in some human cancers is suppressed through hypermethylation.

What is the function of Thrombospondin-2 in humans?

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene. The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.

How big is THBS2 compared to TSP1?

The THBS2 gene is 38,261 bases in size and is composed of 23 exons. Exons 3-22 encode the 5,808 base mRNA. Unlike TSP1, TSP2 is less-to-moderately responsive to serum in mouse NIH3T3 and Swiss 3T3 cells respectively.

How does thrombospondin 2 inhibit breast cancer growth?

“CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo.” Cited for: FUNCTION. “Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.” Complete GO annotation on QuickGO