What is the total organic carbon TOC limit for purified water and water for injection?

500 µg
What is the total organic carbon (TOC) limit for Purified Water and Water for Injection? There is a “target limit response” of 500 µg of Carbon/L. The true limit is the response of the TOC measurement system to a 500 µg Carbon/L (prepared from sucrose) solution, Rs, corrected for the response to reagent water, Rw.

How do you calculate total organic carbon?

TOC is calculated by subtraction of the IC value from the TC of the sample. Another variant employs acidification of the sample to evolve carbon dioxide and measuring it as inorganic carbon (IC), then oxidizing and measuring the remaining non-purgeable organic carbon (NPOC).

Why is total organic carbon bad?

But new research suggests that TOC levels have a direct effect on harmful disinfection byproducts that form during water treatment. DBPs are known to cause bladder cancer and are suspected of causing reproductive problems, including issues during pregnancy.

Do TOC samples need to be refrigerated?

6. Maximum HOLDING TIME FOR SAMPLES is 14 days from time of collection. 7. Alternatively, cool the samples down by placing them overnight in a cooler with wet ice, or in a refrigerator (store chilled for at least 12 hours before packing for shipment).

How does purified water reduce TOC?

Reducing Total Organic Carbon (TOC) in water Reducing TOC in water requires the use of a higher UV energy level created at 185nm wavelength. The TOC Reduction system from ULTRAAQUA uses UV lamps that emits light at this wavelength, with light energy that promotes the formation of OH-radicals from photolysis of water.

What is total organic carbon in water for pharmaceutical use?

Total organic carbon (TOC) determination is an indirect measure of organic substances present in water for pharmaceutical use. TOC determination can also be used to monitor the performance of various operations in the preparation of medicines. A variety of acceptable methods is available for determining TOC.

How much organic carbon is in TOC water?

TOC water. Use highly purified water complying with the following specifications: — conductivity: not greater than 1.0 µS·cm−1at 25 °C, — total organic carbon: not greater than 0.1 mg/l. Depending on the type of apparatus used, the content of heavy metals and copper may be critical. The manufacturer’s instructions should be followed.

What does increase in organic carbon in water mean?

A crucial sign that there is a different, more complex long-chain molecule entering the water system, or that either the quantity of organic molecules present in the water is increasing, is an increase in TOC results in a water system that normally has consistent TOC results.

How is carbon dioxide used to measure TOC?

Specifically, it recommends that TOC analyzers designed for measuring purified water (PW) and water for injection (WFI) fully oxidize the organic contaminants to carbon dioxide to release organic carbon for accurate TOC measurement.