Guidelines

How do you administer foscarnet?

How do you administer foscarnet?

Method of administration: Foscarnet should be administered by the intravenous route only, either by a central venous line or in a peripheral vein. When peripheral veins are used, the solution of foscarnet 24 mg/ml must be diluted.

What is foscarnet used for?

Foscarnet is principally used for the treatment of ganciclovir-resistant cytomegalovirus (CMV) infections in patients with the acquired immunodeficiency syndrome (AIDS) or in transplant recipients.

Which of the following is the side effect of foscarnet?

Side Effects Nausea, vomiting, headache, diarrhea, dizziness, loss of appetite, and increased sweating have been reported. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Which laboratory study should be monitored while patient is taking foscarnet?

Due to FOSCAVIR’s propensity to chelate divalent metal ions and alter levels of serum electrolytes, patients must be monitored closely for such changes. It is recommended that a schedule similar to that recommended for serum creatinine (see above) be used to monitor serum calcium, magnesium, potassium and phosphorus.

How do you administer IV ganciclovir?

The drug should be given as a constant intravenous injection over a minimum of 1 hour. Each dose of ganciclovir is put in 100 or 250 mL bags. The I.V. solution should be warmed up to room temperature before administration.

How is cidofovir administered?

Probenecid must be administered orally with each VISTIDE dose. Two grams must be administered 3 hr prior to the VISTIDE dose and one gram administered at 2 and again at 8 hr after completion of the 1 hr VISTIDE infusion (for a total of 4 grams).

What kind of drug is foscarnet?

Foscarnet is in a class of medications called antivirals. It works by slowing the growth of CMV and HSV. Foscarnet controls CMV retinitis and HSV infections of the skin and mucus membranes but does not cure these infections.

What are the side effects of ganciclovir?

Ganciclovir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • diarrhea.
  • constipation.
  • stomach pain.
  • belching.
  • loss of appetite.
  • changes in ability to taste food.

What are the side effects of Lopinavir?

Side Effects Diarrhea, headache, nausea, vomiting, stomach upset, drowsiness, dizziness, a bad taste in the mouth, and trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Is ganciclovir a hazardous drug?

IN ANIMAL AND IN VITRO STUDIES GANCICLOVIR SODIUM (THE ACTIVE COMPONENT OF THIS PRODUCT) CAUSED ASPERMATOGENESIS, MUTAGENICITY, TERATOGENICITY AND CARCINOGENICITY; THEREFORE, IT SHOULD BE CONSIDERED A POTENTIAL TERATOGEN AND CARCINOGEN IN HUMANS. IT MAY CAUSE BIRTH DEFECTS AND/OR DEATH TO THE EXPOSED FETUS.

Can cidofovir be given IV?

Dosage is based on your medical condition, body weight, and response to treatment. You will usually receive IV fluids before your dose of cidofovir. Your doctor will also direct you to take probenecid by mouth before and after you receive cidofovir.

How much Foscarnet is in a milliliter of Foscavir?

FOSCAVIR INJECTION is a sterile, isotonic aqueous solution for intravenous administration only. The solution is clear and colorless. Each milliliter of FOSCAVIR contains 24 mg of foscarnet sodium hexahydrate in Water for Injection, USP.

What can foscarnet sodium injection be used for?

Foscarnet sodium Injection has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Foscarnet sodium Injection is a sterile, isotonic aqueous solution for intravenous administration only. The solution is clear and colorless.

When do you need to use a dilution for foscarnet?

The standard 24 mg/mL solution may be used with or without dilution when using a central venous catheter for infusion. When a peripheral vein catheter is used, the 24 mg/mL solution must be diluted to 12 mg/mL with 5% dextrose in water or with a 0.9% sodium chloride injection prior to administration to avoid local irritation of peripheral veins.

How is foscarnet used in the treatment of AIDS?

Foscarnet injection is used to treat symptoms of cytomegalovirus (CMV) infection of the eyes in patients with acquired immune deficiency syndrome (AIDS). Foscarnet will not cure CMV eye infection, but it may help to control worsening of the symptoms.