What type of lymphocyte shows abnormal morphology in persistent polyclonal B cell lymphocytosis?

Persistent polyclonal B cell lymphocytosis (PPBL) is a rare disorder, diagnosed primarily in adult female smokers and characterized by an expansion of CD19+CD27+IgM+ memory B cells, by the presence of binucleated lymphocytes, and by a moderate elevation of serum IgM.

What is polyclonal B cell population?

Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare disorder, which mostly affects middle-aged women and is associated with smoking. 1. It is characterized by the persistent expansion of CD27+IgM+IgD+ B cells, the presence of circulating binucleated lymphocytes and increased IgM serum levels.

What is polyclonal B cell activation?

It is well documented that some microbial molecules and microorganisms can directly induce the proliferation and differentiation of antibody-secreting cells from different B cells, regardless of their antigen specificity. This phenomenon is known as polyclonal B cell activation.

What happens when lymphocytes increase in blood?

High lymphocyte blood levels indicate your body is dealing with an infection or other inflammatory condition. Most often, a temporarily high lymphocyte count is a normal effect of your body’s immune system working. Sometimes, lymphocyte levels are elevated because of a serious condition, like leukemia.

Are lymphocytes?

Lymphocytes are white blood cells that are also one of the body’s main types of immune cells. They are made in the bone marrow and found in the blood and lymph tissue.

Are polyclonal B-cells normal?

Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare benign disease with chronic lymphocytosis of polyclonal origin, first described in 1982, which occurs more frequently in middle-aged female smokers. These are mostly mild lymphocytosis and are mostly symptom-free or show unspecific symptoms such as fatigue.

Are polyclonal B cells normal?

Should B cells be polyclonal?

Polyclonal B cell response is a natural mode of immune response exhibited by the adaptive immune system of mammals. It ensures that a single antigen is recognized and attacked through its overlapping parts, called epitopes, by multiple clones of B cell.

When should I worry about high lymphocytes?

When should I be concerned about high lymphocytes?

If your doctor determines that your lymphocyte count is high, the test result might be evidence of one of the following conditions: Infection (bacterial, viral, other) Cancer of the blood or lymphatic system. An autoimmune disorder causing ongoing (chronic) inflammation.

What is the normal percentage of lymphocytes in blood?

Normal Results Lymphocytes: 20% to 40% Monocytes: 2% to 8%

What diseases cause high lymphocytes?

Cancer of the blood or lymphatic system. An autoimmune disorder causing ongoing (chronic) inflammation….Specific causes of lymphocytosis include:

• Acute lymphocytic leukemia.
• Chronic lymphocytic leukemia.
• Cytomegalovirus (CMV) infection.
• Hepatitis A.
• Hepatitis B.
• Hepatitis C.
• HIV/AIDS.
• Hypothyroidism (underactive thyroid)