What is the mechanism of action of lacosamide?

Lacosamide is an antiepileptic drug approved in the USA and Europe as adjunctive therapy for partial-onset seizures. Studies suggest that lacosamide selectively enhances slow inactivation of voltage-gated sodium channels and possibly interacts with collapsin response mediator protein-2.

What is lacosamide made of?

One 20-mL vial contains 200 mg of lacosamide drug substance. The inactive ingredients are sodium chloride and water for injection. Hydrochloric acid is used for pH adjustment.

What type of drug is lacosamide?

Lacosamide is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

Is lacosamide used for nerve pain?

Lacosamide is a sodium-channel blocker that is efficacious in animal models of neuropathic pain. In humans, its effect in neuropathic pain is inconclusive, based on inconsistent results and very large placebo responses. Previous trials have not used patient stratification or looked for predictors for response.

How effective is lacosamide?

Lacosamide is effective and well-tolerated in the short term when used as add-on treatment for drug-resistant focal epilepsy. Lacosamide increases the number of people with 50% or greater reduction in seizure frequency and may increase seizure freedom, compared to placebo.

What is the other name for lacosamide?

Lacosamide (la-COS-a-mide) is the generic name (non-brand name) for the brand drug called Vimpat (VIM-pat) from UCB. It is available in tablet form, a liquid solution, and a liquid for injection.

Why is lacosamide a controlled substance?

Lacosamide oral solution is a federally controlled substance (C-V) because it can be abused or lead to drug dependence. Keep your lacosamide oral solution in a safe place, to protect it from theft. Never give your lacosamide oral solution to anyone else, because it may harm them.

What is neurological pain?

What is neuropathic pain? Neuropathic pain can happen if your nervous system is damaged or not working correctly. You can feel pain from any of the various levels of the nervous system—the peripheral nerves, the spinal cord and the brain. Together, the spinal cord and the brain are known as the central nervous system.

Is lacosamide a brand name?

Lacosamide (la-COS-a-mide) is the generic name (non-brand name) for the brand drug called Vimpat (VIM-pat) from UCB. It is available in tablet form, a liquid solution, and a liquid for injection. Lacosamide is available in many countries, but the name or look may be different.

What are the processes for the synthesis of lacosamide?

The existing processes for the synthesis of R-isomer of Lacosamide comprise unnatural amino acid D-serine or its derivatives as starting material which is costly.

How does Lacosamide work in the MES test?

Lacosamide is a functionalized amino acid that produces activity in the maximal electroshock seizure (MES) test, that, like some other antiepileptic drugs (AEDs), are believed to act through voltage-gated sodium channels.

How does Lacosamide affect sodium channel inactivation?

Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues.

How is lacosamide used in the treatment of seizures?

Lacosamide is an amino acid derivative with a unique anticonvulsant activity that is used in combination with other agents as therapy of partial onset seizures.