What type of transcription factor is Sp1?
What type of transcription factor is Sp1?
Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis.
What is the role of transcription factor Sp1?
Sp1 was the first characterized and still is one of the best studied mammalian transcription factors. It functions as a transcriptional activator of a variety of genes including house-keeping genes, cell cycle regulators and tissue-restricted genes.
Can transcription factors be regulated?
Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes. Regulation of transcription is the most common form of gene control.
What is the function of the transcription factor Sp1?
Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters.
Where does SP1 bind to in the genome?
In the SV40 virus, Sp1 binds to the GC boxes in the regulatory region (RR) of the genome. SP1 belongs to the Sp/KLF family of transcription factors.
Where does SP1 bind to the GC box?
Sp1 transcription factor played an important role in the transcriptional regulation of β1,4GalT V. Sp1 binds to the GC box motif at nucleotide positions −81/−69 of the β1,4GalT V promoter and play an essential role in promoter activity in cancer cells (Sato and Furukawa, 2004). André G. Uitterlinden,
Which is an antibiotic that inhibits SP1?
Inhibitors Plicamycin, an antineoplastic antibiotic produced by Streptomyces plicatus, and Withaferin A, a steroidal lactone from Withania somnifera plant are known to inhibit Sp1 transcription factor. miR-375-5p microRNA significantly decreased expression of SP1 and YAP1 in colorectal cancer cells.
What is the role of transcription factor Sp1 in the different cells?
What is the SP gene?
The SELF PRUNING (SP) gene controls the regularity of the vegetative-reproductive switch along the compound shoot of tomato and thus conditions the ‘determinate’ (sp/sp) and ‘indeterminate’ (SP_) growth habits of the plant.
What is PU 1 transcription factor?
PU. 1 is an E26 transformation-specific family transcription factor that is required for development of the immune system. PU. 1 functions at both early and late stages of lymphoid and myeloid differentiation. At least 110 direct target genes of PU.
Is SP1 a transcriptional activator?
In addition to DNA binding, the zinc-finger motifs may also function in protein-protein interactions that modulate DNA-binding specificity [20,21]. The amino-terminal regions of the Sp1-like/KLF proteins are much more variable and contain transcriptional activation or repression domains.
Is Windows 7 Service Pack 1 still available?
Service Pack 1 (SP1) for Windows 7 and for Windows Server 2008 R2 is now available.
What does SP1 stand for?
SP1
| Acronym | Definition |
|---|---|
| SP1 | Service Pack 1 (Microsoft) |
| SP1 | Serine Protease 1 (enzyme) |
| SP1 | Specific Protein 1 (biochemistry) |
| SP1 | Stimulatory Protein 1 (biochemistry) |
What is the position of the SP1 binding site?
Sp1 binds to the GC box motif at nucleotide positions −81/−69 of the β1,4GalT V promoter and play an essential role in promoter activity in cancer cells (Sato and Furukawa, 2004).
How do I manually install Service Pack 1?
To manually install SP1 from Windows Update:
- Select the Start button > All programs > Windows Update.
- In the left pane, select Check for updates.
- If any important updates are found, select the link to view available updates.
- Select Install updates.
- Follow the instructions to install SP1.
How is Sp1 related to other transcription factors?
Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential biological processes and have been proven important in cell growth, differentiation, apoptosis and carcinogenesis. Sp1 ac …
Where does SP1 bind to a gene promoter?
Analysis of the constitutive transcription factor Sp1, which binds to the Sp1 binding site found in many gene promoters (see Chapter 1, section 1.3.2 ), revealed that the two most potent activation domains contained approximately twenty-five per cent glutamine residues and very few negatively charged residues ( Courey and Tjian, 1988; Fig. 5.3b ).
How are SP1 and sp3 proteins related to cancer?
Sp1 and Sp3 proteins bind to similar, if not the same, DNA tracts and compete for binding, thus they can enhance or repress gene expression. Evidences exist that the Sp-family of proteins regulates the expression of genes that play pivotal roles in cell proliferation and metastasis of various tumors.
Which is the transcription factor responsible for srebp1a activation?
Data demonstrate that the transcription factor SP1 might be the essential factor in SREBP1a activation by CVB3 2A through MEK/ERK signaling pathway. Oncogenic HBXIP controls the transcription regulation of ZEB1 by co-activating Sp1, thereby accelerating breast cancer growth.