What is 17p deletion?

Deletion 17p (del 17p) is a rare genomic aberration found in patients with chronic lymphocytic leukemia (CLL).

What does the 16th chromosome code for?

Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in cells….

What is the 17p chromosome?

Trisomy 17p is a rare chromosomal abnormality resulting from the duplication of the short arm of chromosome 17 and characterized by pre- and post-natal growth retardation, developmental delay, hypotonia, digital abnormalities, congenital heart defects, and distinctive facial features.

What kind of deletions occur in chromosome 17?

One type of deletion that occurs in chromosome 17 is called del 17p, which is common in CLL. This deletion may affect how cancer grows. It is considered a risk factor that may suggest that the disease will progress more quickly. 1-3,6,7 Some people with del 17p may not respond to certain treatments.

Is the del 17p mutation common in CLL?

In fact, more than 80% of people with del 17p also have the TP53 mutation. 6 When part of a chromosome is missing, it’s called a deletion. One type of deletion that occurs in chromosome 17 is called del 17p, which is common in CLL. This deletion may affect how cancer grows.

What do you need to know about chromosome 17p duplication?

Summary Summary. Listen. Chromosome 17p duplication is a chromosome abnormality that occurs when there is an extra copy of genetic material on the short arm (p) of chromosome 17. The severity of the condition and the signs and symptoms depend on the size and location of the duplication and which genes are involved.

What does del17p in multiple myeloma mean?

What the deletion of 17p means is that a portion of chromosome 17 on the short arm (which is what the p stands for) is actually deleted. When mapping has been done to try to identify what genes are mutated as a result, the gene that is most commonly found to be lost is the gene called p53.