What is metabolomic study?

Metabolomics is the large-scale study of small molecules, commonly known as metabolites, within cells, biofluids, tissues or organisms. Collectively, these small molecules and their interactions within a biological system are known as the metabolome.

What is metabolic fingerprinting?

Metabolic fingerprinting is a rapid and noninvasive analysis, representing a powerful approach for the characterization of phenotypes and the distinction of specific metabolic states due to environmental alterations.

What is the meaning of metabolome?

The metabolome has been defined as the qualitative and the quantitative collection of all low-molecular-weight molecules (metabolites) present in the cell that are participants in general metabolic reactions and that are required for the maintenance, growth, and normal function of a cell.

How is Metabolomics used to diagnose toxicity?

External stressors can cause phenotypic changes. While metabolomics, in which endogenous metabolites are identified and quantified, is widely regarded to be the omics approach that is closest to the phenotype. Metabolomics has been proven helpful to reveal toxicological mechanisms based on metabolic pathway analysis.

How is the metabolome similar to transcriptomics and proteomics?

The word was coined in analogy with transcriptomics and proteomics; like the transcriptome and the proteome, the metabolome is dynamic, changing from second to second. Although the metabolome can be defined readily enough, it is not currently possible to analyse the entire range of metabolites by a single analytical method.

Who are the leading scientists in metabolomics research?

Recent efforts to utilize NMR for metabolomics have been largely driven by the laboratory of Jeremy K. Nicholson at Birkbeck College, University of London and later at Imperial College London.

How are metabolomics and transcriptomics related to nutrition?

Nutrigenomics is a generalised term which links genomics, transcriptomics, proteomics and metabolomics to human nutrition. In general a metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.