What drug class is nordiazepam?

It has a role as a GABA modulator, an anxiolytic drug, an anticonvulsant, a sedative and a human metabolite. It is a 1,4-benzodiazepinone and an organochlorine compound. Nordiazepam is a DEA Schedule IV controlled substance.

What are the metabolites of Librium?

The metabolic pathway of chlordiazepoxide is complex, since the drug is biotransformed into a succession of pharmacologically active products: desmethylchlordiazepoxide, demoxepam, desmethyldiazepam, and oxazepam.

What is nordiazepam a metabolite of?

The primary urinary metabolite, nordiazepam (desmethyldiazepam), undergoes subsequent metabolic transformation into oxazepam. Temazepam, another active metabolite of diazepam, also undergoes further metabolic transformation into oxazepam.

What is the classification of benzodiazepines?

The Drug Enforcement Agency (DEA) classify benzodiazepines as a Schedule IV controlled substance. According to the classification, these drugs have a low potential for abuse and low risk of dependence.

Is Librium a benzo?

Librium (chlordiazepoxide) is a benzodiazepine used to treat anxiety disorders or alcohol withdrawal.

What are the metabolites of lorazepam?

Metabolites present were lorazepam glucuronide, a quinazolinone, a quinazoline carboxylic acid, and two hydroxylorazepam isomers, one of which is novel, having the hydroxyl group located on the fused chlorobenzene ring.

What does Librium look like?

Generic Name: chlordiazepoxide Pill with imprint LIBRIUM 25 ROCHE is Green & White, Capsule-shape and has been identified as Librium 25 mg. It is supplied by ICN Pharmaceuticals Inc. Librium is used in the treatment of alcohol withdrawal; anxiety; light sedation and belongs to the drug class benzodiazepines.

Does Librium lower BP?

The Dangers of Librium Librium slows down the user’s central nervous system and as a result, chronic misuse of the drug can have dangerous health consequences. Abuse of Librium can cause impaired cognitive and physical function, including a drastic decrease in blood pressure and heart rate.

What are the strongest benzodiazepines in order?

High-potency Benzodiazepine List

• alprazolam (Xanax)
• lorazepam (Ativan)
• triazolam (Halcion)

What are the names of barbiturates?

Barbiturates are available under the following different brand names: amobarbital (Amytal), secobarbital (Seconal), butabarbital (Butisol), pentobarbital (Nembutal), belladonna and phenobarbital (Donnatal), butalbital/acetaminophen/caffeine (Esgic, Fioricet), and butalbital/aspirin/caffeine (Fiorinal Ascomp, Fortabs).

Is Librium stronger than diazepam?

Librium (chlordiazepoxide) is good for lowering anxiety since its effects aren’t as strong as similar medicines; however, it lasts longer in the body and can be more dangerous in older people. Helps you relax. Valium (diazepam) is effective for occasional or short-term use for anxiety and muscle spasm.

How is nordiazepam metabolized in the body?

Practical Pain Management explains that diazepam is metabolized into two primary metabolites, one of which is nordiazepam. This is the primary urinary metabolite which is then metabolized further into oxazepam.

How is chlordiazepoxide and oxazepam metabolized?

Diazepam → Nordiazepam, Oxazepam, and Temazepam. Chlordiazepoxide is metabolized to nordiazepam and oxazepam; all may be detected after chlordiazepoxide use. Chlordiazepoxide → Nordiazepam and Oxazepam. Alprazolam is detected as the metabolite α-hydroxyalprazolam.

Why does nordazepam have a different half life than other drugs?

The variation of reported half-lifes are attributed to differences in nordazepam metabolism and that of its metabolites as nordazepam is hydroxylated to active metabolites such as oxazepam, before finally being glucuronidated and excreted in the urine.

How is nordazepam used in the treatment of anxiety?

Nordazepam. Like other benzodiazepine derivatives, it has amnesic, anticonvulsant, anxiolytic, muscle relaxant, and sedative properties. However, it is used primarily in the treatment of anxiety disorders. It is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, pinazepam, and medazepam.