How do you administer metalyse?

METALYSE should be administered to the patient, intravenously over 5 to 10 seconds. It should not be administered into a line containing dextrose. Any unused solution should be discarded. Alternatively the reconstitution can be performed with the included needle.

When do you use metalyse?

Metalyse is used to treat adults suspected of having an acute myocardial infarction (heart attack) within six hours of the first symptoms appearing. It is used to dissolve the blood clots that have formed inside the blood vessels supplying the heart. The medicine can only be obtained with a prescription.

How do you dilute metalyse?

Metalyse should be reconstituted by adding the complete volume of water for injections from the pre-filled syringe to the vial containing the powder for injection.

1. Ensure that the appropriate vial size is chosen according to the body weight of the patient.
2. Check that the cap of the vial is still intact.

What is half life of tenecteplase?

Tenecteplase and r-tPA plasma concentrations were measured for 6 hours. Tenecteplase exhibited biphasic elimination from the plasma with a mean initial half-life of 22 minutes and a mean terminal half-life of 115 minutes.

What is the difference between tPA and tNK?

tNK is cheaper than tPA in many locales. tNK requires a bolus injection over five to 10 seconds rather than the infusion required to administer tPA. And clinical trials show similar results in thrombolysis.

How do you reteplase an injection?

Reteplase should be administered via an IV line in which no other medication is being simultaneously injected or infused. Do not add any other medications to the injection solution.

Is streptokinase an anticoagulant?

Streptokinase (SK) is a thrombolytic medication and enzyme. As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism….Streptokinase.

What is the generic name for metalyse?

Tenecteplase is a tissue plasminogen activator (t-PA) produced by recombinant DNA technology, using an established mammalian cell line (Chinese Hamster Ovary cells). Tenecteplase is a recombinant plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure.

How do you calculate noradrenaline infusion?

4mg = 4mL of 1:1000 Add 4mL of 1:1000 Noradrenaline to 46mL 5% Glucose to make 50mL Place in a syringe driver. Below is the infusion table – the rate in mL/hour is given in the box and depends on the weight of the patient (vertical) and the desired rate of infusion (horizontal).

Is there a reversal agent for tenecteplase?

In the event of serious bleeding, heparin and antiplatelet agents should be discontinued immediately. Heparin effects can be reversed by protamine. Readministration of plasminogen activators, including TNKase, to patients who have received prior plasminogen activator therapy has not been systematically studied.

What class of drug is reteplase?

Retavase® (Reteplase) is a non-glycosylated deletion mutein of tissue plasminogen activator (tPA), containing the kringle 2 and the protease domains of human tPA.

Is there a maximum dosage of Metalyse 10, 000 units?

Metalyse should be administered on the basis of body weight, with a maximum dose of 10,000 units (50 mg tenecteplase). The volume required to administer the correct dose can be calculated from the following scheme: For details see section 6.6: Special precautions for disposal and other handling

What kind of injection is Metalyse used for?

Metalyse is a powder and a solvent that are made up into a solution for injection. It contains the active substance tenecteplase. What is Metalyse used for? Metalyse is used to treat adults suspected of having an acute myocardial infarction (heart attack) within six hours of the first symptoms appearing.

How often do you have to take Metalyse?

Metalyse is given once as a single injection into a vein over around 10 seconds. The dose to be given is adjusted according to the patient’s weight (see the package leaflet). In addition to Metalyse, the patient should also be treated with other medicines that are used to prevent blood clots such as aspirin and heparin. How does Metalyse work?

How many units of tenecteplase are in 10, 000 units?

1. Name of the medicinal product Metalyse 10,000 units powder and solvent for solution for injection 2. Qualitative and quantitative composition Each vial contains 10,000 units (50 mg) tenecteplase. Each pre-filled syringe contains 10 ml solvent. The reconstituted solution contains 1,000 units (5 mg) tenecteplase per ml.