What is the antidote for heparin-induced thrombocytopenia?

Thrombocytopenia should be treated with transfusion of washed platelets. Excessive anticoagulation associated with danaparoid can completely be reversed with protamine sulfate. In patients with a history of HIT, heparin can safely be used intraoperatively during cardiac surgery.

What drug is used for the treatment of heparin-induced thrombocytopenia?

Bivalirudin and fondaparinux have been used to treat HIT in small case series. New oral anticoagulants, such as factor IIa and factor Xa inhibitors, may provide a novel treatment approach in HIT. Summary: First-line therapies for HIT are argatroban or lepirudin.

What is heparin-induced thrombocytopenia and how is it treated?

Patients with HIT are at high risk for thrombotic events and should be treated with alternative anticoagulants, typically a direct thrombin inhibitor (DTI). The US Food and Drug Administration (FDA) has approved the DTI argatroban (Acova) for prophylaxis and treatment of thrombosis in patients with HIT.

What are the symptoms of HIT?

What Are the Symptoms of HIT?

• Skin tenderness.
• Swelling.
• Skin that’s warm to the touch.
• Shortness of breath.
• Change in heart rate.
• Sharp pain in your chest.
• Dizziness.
• Anxiety.

How does heparin induced thrombocytopenia ( HIT ) work?

Go to: Abstract Heparin‐induced thrombocytopenia (HIT) is a potentially devastating immune mediated adverse drug reaction caused by the emergence of antibodies that activate platelets in the presence of heparin.

What are the alternatives to heparin for thrombocytopenia?

Heparin-induced thrombocytopenia. Several alternatives are available for this purpose and mainly used are danaparoid, fondaparinux, argatroban and bivalirudin. While heparin was discovered in the 1930s, HIT was not reported until the 1960s.

What happens if you get hit with heparin?

MONITORING FOR HIT HIT can lead to life- and limb-threatening complications where a delay in diagnosis or inappropriate continuation of heparin could increase harm to the patient.

What kind of thrombosis is caused by heparin?

When thrombosis is identified the condition is called heparin-induced thrombocytopenia and thrombosis (HITT). HIT is caused by the formation of abnormal antibodies that activate platelets.