What is reciprocal and non reciprocal translocation?

Nonreciprocal translocations are one-way translocations in which a chromosomal segment is transferred to a nonhomologous chromosome. Reciprocal translocations, on the other hand, involve the exchange of segments from two nonhomologous chromosomes.

What causes telomere dysfunction?

In humans, telomere dysfunction occurs during normal ageing, and critically short telomeres have been reported as a common early alteration in many epithelial cancers [16], [17], the prevalent tumour type in the elderly.

Do telomeres reduce chromosome translocation?

Telomeres contain terminal DNA sequence repeats that maintain chromosomal stability. Telomeres shorten with cell division and may become dysfunctional leading to chromosomal instability.

What is an example of reciprocal translocation?

A prototypical example of this phenomenon is represented by the Philadelphia chromosome associated with human lymphoma/leukemia. This specific chromosomal abnormality consists of a translocation between the long arms of chromosomes 9 and 22 and is seen in 85% of patients with chronic myelogenous leukemia.

What are the two types of translocation?

There are two main types of translocations: reciprocal and Robertsonian. In a reciprocal translocation, two different chromosomes have exchanged segments with each other. In a Robertsonian translocation, an entire chromosome attaches to another at the centromere.

What food contains telomerase?

3.1. Telomere length is positively associated with the consumption of legumes, nuts, seaweed, fruits, and 100% fruit juice, dairy products, and coffee, whereas it is inversely associated with consumption of alcohol, red meat, or processed meat [27,28,33,34].

Who has longer telomeres?

Compared with women who had their last child by the age of 29, women with a later age at birth of last child (34–37 years or ≥38 years old) were found to have increased odds of being in the longest tertile of telomere length versus the shortest tertile of telomere length when adjusting for covariates.

What happens to chromosomes Without telomerase?

They protect the ends of our chromosomes by forming a cap, much like the plastic tip on shoelaces. If the telomeres were not there, our chromosomes may end up sticking to other chromosomes. Without telomeres, important DNA would be lost every time a cell divides (usually about 50 to 70 times).

How telomeres are lost?

In addition to gradual telomere shortening during cell division, the loss of telomere function can also occur as a result of stochastic events in which large blocks of telomeric repeat sequences are lost in a single rapid deletion event.

What are the two types of translocations?

What phase does translocation occur?

Translocations occur when chromosomes become broken during meiosis and the resulting fragment becomes joined to another chromosome.

What is translocation example?

Examples

https://www.youtube.com/watch?v=CfsE_klDhhM