How does SREBP work?

Once in the nucleus, SREBP can bind to specific DNA sequences (the sterol regulatory elements or SREs) that are found in the control regions of the genes that encode enzymes needed to make lipids. This binding to DNA leads to the increased transcription of the target genes.

How is SREBP regulated?

SREBP processing is mainly controlled by cellular sterol content. When sterol levels decrease, the precursor is cleaved to activate cholesterogenic genes and maintain cholesterol homeostasis.

How does Srebp 2 regulate HMG CoA reductase?

Transcriptional regulation of HMG-CoA reductase by SREBP-2. SREBP-2 is an important transcription factor that binds to the promoter region of HMG-CoA reductase to regulate its gene expression. Sp1 is a transcription factor that binds to the promoter region of SREBP-2 gene to regulate its transcription.

What is SREBP what role does it play in cholesterol homeostasis?

In the health arena, SREBPs stand at a crucial point: They regulate expression of the LDL receptor, the molecule which enables the hepatocytes to remove cholesterol contained in LDL particles from the bloodstream.

What is the function of sterol regulatory element?

Sterol regulatory element binding proteins (SREBPs) are membrane-bound transcription factors that activate genes involved in cholesterol synthesis. They provide the means by which cellular cholesterol exerts negative feedback on cholesterol synthesis.

What is insig?

Insigs are sensors and mediators that regulate cholesterol homeostasis through binding to SCAP and HMG-CoA reductase in diverse tissues such as adipose tissue and liver, as well as the cultured cells. In this article, we aim to review on the dual functions of Insig protein family in cholesterol homeostasis.

What is the function of HMG-CoA reductase?

HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of hypocholesterolemic drug therapy.

Where does mevalonate pathway occur?

In higher plants, the MEP pathway operates in plastids while the mevalonate pathway operates in the cytosol. Examples of bacteria that contain the MEP pathway include Escherichia coli and pathogens such as Mycobacterium tuberculosis.

What is SCAP cholesterol?

SCAP is an integral membrane protein located in the endoplasmic reticulum (ER). One of the cytosolic regions of SCAP contains a hexapeptide amino acid sequence, MELADL, that functions to detect cellular cholesterol.

What is insig used for?

What Insig is used for. Insig belongs to a group of medicines called diuretics. It is used either alone or with other medicines to treat: mild to moderate hypertension (high blood pressure).

What is insig health?

INSIG is a leading Canadian virtual care platform with a unique SaaS-enabled marketplace currently supporting over 2,800 healthcare practitioners with approximately 200,000 virtual care appointments(1) served in the last 90 days. The platform has been used by over 500,000 patients(2) since inception.

Which is sterol regulatory element binding protein 1A?

X-ray crystallography of Sterol Regulatory Element Binding Protein 1A with polydeoxyribonucleotide. Sterol regulatory element-binding proteins ( SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes SREBF1 and SREBF2.

How is SREBP-2 related to the sterol regulatory element?

SREBP-2 regulates the genes of cholesterol metabolism. SREB proteins are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. These proteins work with asymmetric sterol regulatory element (StRE).

How are SREB proteins required for cholesterol biosynthesis?

SREB proteins are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. These proteins work with asymmetric sterol regulatory element (StRE).

How are SREBPs similar to E box binding proteins?

SREBPs have a structure similar to E-box -binding helix-loop-helix (HLH) proteins. However, in contrast to E-box-binding HLH proteins, an arginine residue is replaced with tyrosine making them capable of recognizing StREs and thereby regulating membrane biosynthesis.