What does Hyperthecosis mean?

The term hyperthecosis refers to the presence of nests of luteinized theca cells in the ovarian stroma due to differentiation of the ovarian interstitial cells into steroidogenically active luteinized stromal cells (picture 1). The result is greater production of androgens.

What causes Hyperthecosis?

Hyperthecosis occurs when an area of luteinization occurs along with stromal hyperplasia. The luteinized cells produce androgens, which may lead to hirsutism and virilization (or masculinization) in affected women.

What is ovarian stroma?

The stroma of the ovary is a unique type of connective tissue abundantly supplied with blood vessels, consisting for the most part of spindle-shaped stroma cells. These appear similar to fibroblasts. The stroma also contains ordinary connective tissue such as reticular fibers and collagen.

What is ovarian stromal hyperplasia?

Stromal hyperplasia is the nodular or diffuse proliferation of the ovarian stroma, whereas OHT is stromal proliferation accompanied by luteinised stromal cells [5]. They present with hyperandrogenism, obesity, hyperinsulinaemia, acanthosis nigricans, and even virilization, mainly in postmenopausal women [2].

What is Luteoma pregnancy?

Abstract. Pregnancy luteomas are rare, benign, neoplasms of the ovary thought to be caused by the hormonal effects of pregnancy. They are usually asymptomatic and found incidentally during imaging or surgery.

What is a Thecoma?

Definition. Thecomas are defined as stromal tumors that resemble thecal cells of the developing follicle and that are composed of a minimum (less than 10%) of cells with granulosa cell differentiation. They are only one-third as common as granulosa cell tumors and account for less than 1% of all ovarian tumors.

What is hair an Syndrome?

HAIR-AN syndrome is a condition that affects women. It is characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans. Insulin resistance is a condition in which the body produces insulin but does not use it properly. This causes the pancreas to produce more insulin.

What is increased stroma in ovary?

Abstract. Since the widespread use of transvaginal ultrasound to diagnose polycystic ovary syndrome (PCOS), a cardinal feature has been shown to be the presence of a bright, highly echogenic stroma. This is usually assessed subjectively. polycystic ovary syndrome.

What is theca cells?

Theca cells are the endocrine cells associated with ovarian follicles that play an essential role in fertility by producing the androgen substrate required for ovarian estrogen biosynthesis. Theca cells differentiate from the interfollicular stroma in response to proteins secreted from growing follicles.

What is a Luteoma?

Pregnancy luteomas are rare, benign, neoplasms of the ovary thought to be caused by the hormonal effects of pregnancy. They are usually asymptomatic and found incidentally during imaging or surgery.

What is Luteomas?

Can a MRI be used to diagnose ovarian hyperthecosis?

Role of MRI is yet to be proven. Symmetric bilateral ovarian enlargement, with homogeneous T2-hypointensity and mild enhancement of the ovaries, may be seen. A CT or MRI of the adrenals is important for women with high levels of DHEA-S.

What happens to your body when you have hyperthecosis?

Hyperthecosis occurs when an area of luteinization occurs along with stromal hyperplasia. The luteinized cells produce androgens, which may lead to hirsutism and virilization (or masculinization) in affected women.

When does hyperthecosis occur in the ovarian stroma?

Hyperthecosis occurs when an area of luteinization occurs along with stromal hyperplasia. The luteinized cells produce androgens, which may lead to hirsutism and virilization (or masculinization) in affected women. The term hyperthecosis refers to the presence of nests of luteinized theca cells in the ovarian stroma due…

What kind of treatment is used for hyperthecosis?

Treatment for hyperthecosis is based upon each case, but may range from pharmacological interventions to surgical. ^ Stead, Stead, Kaufman, Suarez (2009).