What is the function of CD68?

CD68 has been shown to bind oxLDL, phosphatidylserine, apoptotic cells and serve as a receptor for malaria sporozoite in liver infection. CD68 is mainly located in the endosomal/lysosomal compartment but can rapidly shuttle to the cell surface. However, the role of CD68 as a scavenger receptor remains to be confirmed.

What does CD68 positive mean?

Fibrolamellar carcinomas are positive for CD68. Increased numbers of CD68-positive tumor macrophages indicate an adverse overall outcome in Hodgkin lymphoma. Significant co-localization of CD36 receptor with cells of the macrophage lineage, such as CD68 positive cells.

What are CD68 cells?

CD68 is a sialomucin and a member of the scavenger receptor supergene family [5, 108]. This molecule is expressed by monocytes and macrophages as well as subsets of CD34-positive hematopoietic stem cells, dendritic cells, neutrophils, basophils, and mast cells [5, 109, 110].

What is CD68 antibody?

CD68, also known as Gp110 or macrosialin, is a type I transmembrane glycoprotein of 110kDa. In a more recent study, the CD68 antibody KP1 was used by Gollapudi et al as a marker of tumour-associated macrophages in prostatectomy samples from individuals with prostate cancer.

What is CD45 a marker for?

CD45 is used as a marker of all hematopoietic cells (blood cells), except for mature erythrocytes (red blood cells) and platelets.

What is a pan macrophage marker?

CD68 is a pan-macrophage marker frequently used as a marker for TAMs. However, CD68 recognizes both tumoricidal M1 and anti-inflammatory M2 macrophages. This may explain previous contradictory data showing that dense infiltration of TAMs was correlated to both good and poor patient outcome [8].

What is Pancytokeratin?

In surgical pathology, it is an important marker for carcinoma as well as some special tumor types which have an epithelial component or differentiation. This cocktail has been used to differentiate epithelial from non-epithelial tumors.

What does CD45+ mean?

CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.

What cells are CD45 +?

CD45 antigen (leukocyte common antigen), a unique and ubiquitous membrane glycoprotein with a molecular mass of about 200 kDa, is expressed on almost all hematopoietic cells except for mature erythrocytes.

What is a pan marker?

Pan T Cell marker (15-6A1) is a mouse monoclonal antibody raised against raised against WAG/Rij lymph node cells of rat origin.

Is cytokeratin and keratin same?

Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue. They are an important component of intermediate filaments, which help cells resist mechanical stress. Expression of these cytokeratins within epithelial cells is largely specific to particular organs or tissues.

How is CD68 expression regulated in macrophages?

PMID: 18405323 DOI: 10.1111/j.1365-3083

Can a CD68 antibody react with othe?

However, several immunohistochemical studies have indicated that CD68 antibodies also react with othe … Expression of CD68 in non-myeloid cell types Scand J Immunol. 2008 May;67(5):453-63.doi: 10.1111/j.1365-3083

Where are CD68 proteins found in the body?

Some non-hematopoietic cells, such as epithelium of renal tubules, may show CD68 positivity [5, 111]. CD68 is a protein found in the granules of macrophages, which includes not just the standard tissue macrophage but some such cells that are given specific names in certain organs.

Why do we need to co label cells with CD68?

Macrophages play a critical role in the cross-talk between lymphocytes with inflammation and between cancer cells in cancer progression. Thus, we often want to co-label cells positive for a certain protein, DNA, or RNA marker after immunohistochemistry or in situ hybridization to prove they are macrophages. In such cases, CD68 is the best choice.