What is familial lipodystrophy?

Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective, progressive loss of body fat (adipose tissue) from various areas of the body. Individuals with FPL often have reduced subcutaneous fat in the arms and legs and the head and trunk regions may or may not have loss of fat.

How is lipodystrophy diagnosed?

The diagnosis of lipodystrophy is usually made clinically based on history, body distribution of adipose tissue, physical examination, and metabolic profile. Lipodystrophy should be suspected in any person with partial or complete lack of subcutaneous adipose tissue.

What is FPLD?

Familial partial lipodystrophy (FPLD) is a group of diseases characterized by an abnormal distribution of fat around the body. Specifically, fat is lost in the arms, legs, and hips, and gained around the face and liver.

Does lipodystrophy make you fat?

People with lipodystrophy will have disproportionate fat accumulation on the body. This rare condition has many different forms and can be genetic or acquired. Anyone with concerns about lipodystrophy should speak to a doctor for a diagnosis.

How do you treat lipodystrophy?

Treatment

1. Tesamorelin (Egrifta), a daily shot that can lessen belly fat but may raise your blood sugar.
2. Metformin (Glucophage) for high blood sugar and insulin resistance.
3. Atorvastatin (Lipitor) or rosuvastatin (Crestor) for high cholesterol.

Is lipodystrophy painful?

Lipodystrophy in panniculitis-associated AGL is preceded by the development of painful subcutaneous nodules or lesions consisting of small spots or bumps (maculopapular lesions). Individuals with autoimmune-associated AGL have past or present evidence of an autoimmune disorder in addition to lipodystrophy.

How do you fight lipodystrophy?

What is the difference between lipodystrophy and Lipohypertrophy?

Insulin lipohypertrophy denotes to a benign tumor like swelling of fatty tissue at the injection site secondary to lipogenic effect of insulin, whereas lipoatrophy is considered an adverse immunological side effect of insulin therapy.

What is acquired partial lipodystrophy?

Barraquer-Simons syndrome , or acquired partial lipodystrophy, is characterized by the loss of fat from the face, neck, shoulders, arms, forearms, chest and abdomen. Occasionally the groin or thighs are also affected. Onset usually begins in childhood following a viral illness. It affects females more often than males.

What is the life expectancy of someone with lipodystrophy?

Age at death (years-old) of Berardinelli-Seip Congenital Lipodystrophy patients according to the year of death. Life expectancy for the study population was 62.9±4.8 years. The potential number of years of life lost was 35.6±16.6 years.

Is lipodystrophy serious?

Depending on which type of lipodystrophy a person has, it may cause other problems, including diabetes, high cholesterol and triglycerides, liver disease, and kidney failure. Doctors can help you manage these complications. And cosmetic surgery might be an option if looks are a concern.

How long does it take to develop lipodystrophy?

Lipodystrophy associated with PIs occurs 2-12 months after starting PI therapy. Previous reports have shown that ritonavir-saquinavir combinations have a stronger association with abnormal fat accumulation than indinavir or nelfinavir.

How does familial partial lipodystrophy affect the body?

Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective, progressive loss of body fat (adipose tissue) from various areas of the body. Individuals with FPL often have reduced subcutaneous fat in the arms and legs and the head and trunk regions may or may not have loss of fat.

Is there such a thing as complete lipodystrophy?

Lipodystrophy is a general term for a group of disorders that are characterized by complete (generalized) or partial loss of adipose tissue. In addition to FPL, there are other inherited forms of lipodystrophy.

When was familial partial lipodystrophy-Nord first described?

The loss of adipose tissue that characterizes these disorders is sometimes referred to as lipoatrophy rather than lipodystrophy by some physicians. FPL was first described in the medical literature in 1970s independently by three groups of physicians, including Doctors Ozer, Kobberling and Dunnigan.

What does congenital generalized lipodystrophy ( CGL ) mean?

Congenital generalized lipodystrophy (CGL), also known as Berardinelli-Seip syndrome, is a rare genetic disorder characterized by the loss of body fat (adipose tissue). In CGL, there is often a near total loss of body fat that is present at birth (congenital).