What is podoplanin a marker for?

Podoplanin has become a useful immunohistochemical marker for identifying mesothelioma. Through tissue staining, pathologists use podoplanin to tell the difference between epithelioid mesothelioma and adenocarcinoma — a type of cancer that forms in the mucus-secreting membranes throughout the body.

What cells express podoplanin?

In addition to squamous cell carcinomas, podoplanin expression was shown in germ cell tumors of the ovary [26], angiosarcomas [11], osteosarcomas, where its level was significantly higher in metastases in comparison to primary tumors [50], mesotheliomas [25,51,52], basal cell carcinomas of the skin [53], and follicular …

What is podoplanin?

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system.

In which tissues PDPN is mostly expressed transcribed?

PDPN) is transcribed in cells derived from sarcomas, embryonal carcinomas, squamous cell carcinomas and endometrial tumours, while cell lines derived from colon, pancreatic, ovarian and ductal breast carcinomas do not express PDPN transcripts.

What is lymphatic endothelial cells?

Lymphatic endothelial cells (LECs) form the structure of the lymphatic vessels and the sinuses of the lymph nodes, positioning them to be key players in many different aspects of the immune response. Following an inflammatory stimulus, LECs produce chemokines that recruit immune cells to the lymph nodes.

Which area does not contain malt?

Terms in this set (21) Which area does not contain MALT? right foot.

Are lymphatic capillaries open at both ends?

Lymphatic Capillaries. Lymph capillaries are tiny, thin-walled vessels, closed at one end and located in the spaces between cells throughout the body.

Where is MALT found in the body?

Mucosa-associated lymphoid tissue (MALT) is scattered along mucosal linings in the human body [1, 2, 3] and constitutes the most extensive component of human lymphoid tissue. These surfaces protect the body from an enormous quantity and variety of antigens.

What is MALT in the immune system?

The mucosa-associated lymphoid tissue (MALT) initiates immune responses to specific antigens encountered along all mucosal surfaces. MALT inductive sites are secondary immune tissues where antigen sampling occurs and immune responses are initiated.

What is the largest lymphatic organ in the human body?

Spleen
Spleen: This largest lymphatic organ is located on your left side under your ribs and above your stomach. The spleen filters and stores blood and produces white blood cells that fight infection or disease. Thymus: This organ is located in the upper chest beneath the breast bone.

How does MALT work in the body?

A heart-healthy mix, malt contains fiber, potassium, folate, and vitamin B6, which together lower cholesterol and decrease the risk of cardiac disease. Its dietary fiber helps reduce insulin activity and increases cholesterol absorption from the gut and encourages cholesterol breakdown.

What kind of protein is the PDPN gene?

Podoplanin is a protein that in humans is encoded by the “PDPN” gene. Podoplanin is a mucin -type protein with a mass of 36- to 43-kDa.

Where is the PDPN located in a tumor?

Yong Song, in The International Journal of Biochemistry & Cell Biology, 2017 The mucin-type sialoglycoprotein podoplanin (PDPN, also named as Aggrus) is located on tumor cell surface and involved in TCIPA as well as tumor metastasis (Fujita and Takagi, 2012 ).

What kind of diseases are associated with PDPN?

PDPN (Podoplanin) is a Protein Coding gene. Diseases associated with PDPN include Lymphangioma and Subglottis Neoplasm.

What is the role of PDPN in the immune system?

However, more recent studies have revealed that PDPN also plays crucial roles in the biology of immune cells, including T cells and dendritic cells. This review will provide a comprehensive overview of the diverse roles of PDPN in development, immunology, and cancer. Podoplanin (PDPN) is a 36- to 43-kDa mucin-type transmembrane protein.