Is MTHFR related to fibromyalgia?

MTHFR A1298C mutations are tied to higher levels of fibromyalgia, IBS, fatigue, chronic pain, schizophrenia, and mood-related problems. This is especially true if you’ve inherited the mutation from both parents or have both forms of MTHFR mutations.

How is MTHFR A1298C treated?

How to treat the MTHFR gene mutation? The doctor may suggest supplementation to address deficiencies, along with medications or treatments to address the specific health condition. Treatments for any disease caused by the MTFR mutation (e.g., for depression antidepressants) may be prescribed.

How common is A1298C mutation?

Another mutation called MTHFR A1298C is found in 7% to 12% of North American, European, and Australian populations and is less common in Hispanics (4%–5%), Chinese (1%–4%), and Asians (1%–4%). Being homozygous for MTHFR A1298C leads to 60% of normal enzyme function.

What is A1298C mutation?

The A1298C mutation, like the C677T mutation, results in a decrease in MTHFR activity that is more pronounced in the homozygous (CC) than in the heterozygous (AC) or normal (AA) states, and does not result in a thermolabile protein.

What are the symptoms of MTHFR?

Symptoms of a MTHFR mutation

• cardiovascular and thromboembolic diseases (specifically blood clots, stroke, embolism, and heart attacks)
• depression.
• anxiety.
• bipolar disorder.
• schizophrenia.
• colon cancer.
• acute leukemia.
• chronic pain and fatigue.

What supplements should I take for MTHFR mutation?

It’s important to opt for a supplement that contains the most bioavailable form of folate—methyl-folate—which can help your body absorb the vitamin more efficiently. Additional supplements that help support this genetic variant include magnesium, vitamin D , and vitamin B6.

What foods to avoid if you have the MTHFR gene mutation?

Avoid all products with added or fortified folic acid which is the synthetic form of vitamin B9 found in fortified supplements (pregnancy supplements) breads, cereals and commercially produced flours. Avoid processed foods that have synthetic folic acid added to them.

Does L Methylfolate cause weight gain?

In addition, L-methylfolate augmentation did not lead to any significant differences in terms of gastrointestinal side effects, sedation, weight gain, and sexual dysfunctions.

What supplements to avoid with Mthfr?

Is there any information on the A1298C mutation?

There is little known about the A1298C MTHFR mutation. Or so it seems. Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory. For those who have the A1298C MTHFR mutation, this is frustrating.

What happens if you have a mutation in MTHFR A1298C?

If you have a mutation in your MTHFR A1298C gene, your body is impacted very differently from a mutation at MTHFR C677T or MTHFR 03. Most people mean MTHFR C677T when they refer to MTHFR, because it is a common mutation and it has a major impact.

Are there any vitamins or minerals for A1298C?

Since MTHFR mutations are so varied and unique to each individual, the perfect vitamins and nutrients for your gene type may not be the same as mine. That’s why I always suggest working with an MTHFR-literate doctor. There are a few a1298c supplements, however, that are widely considered good for everyone with the a1298c mutation.

What are the differences between MTHFR A1298C and C677T?

A double whammy if you will. One of the major differences between a1298c and c677t mutations, apart from their gene makeup, lies in their inabilities. MTHFR C677T mutations cause problems in converting folic acid into its active, bioavailable form – folate. An a1298c mutation affects the change of methylfolate into tetrahydrobiopterin or BH4.