How does the Cellsearch system work?

> How does the CELLSEARCH® System work? The CELLSEARCH® System uses unique technology to capture, isolate, and enumerate circulating tumor cells (CTCs) from a 7.5-mL blood sample.

How are circulating tumor cells detected?

The most widely used approach for CTC detection and isolation is immune-based detection, whereby antibodies are used to selectively bind cell surface antigens [11]. Tumor cells express different cell surface markers than blood cells and therefore can be separated from the circulatory cells.

How accurate is the CTC test?

The high accuracy of the ISET-CTC test combined with the 97% sensitivity and 99% specificity of the PSA-marker presence on prostate cancer cells, suggests an estimated positive predictive value (PPV) of 99% and a negative predictive value (NPV) of 97% for this novel screening test.

What is veridex?

About Veridex, LLC Veridex, LLC, a Johnson & Johnson company, is an organization dedicated to providing physicians with high-value diagnostic oncology products. Veridex IVD products may significantly benefit patients by helping physicians make more informed decisions that enable better patient care.

What is CTC blood test?

The CellSearch Circulating Tumor Cell (CTC) test is a simple blood test that helps oncologists in assessing the prognosis of patients with metastatic breast, colorectal, or prostate cancer. The CellSearch test is the only FDA-approved test for CTC assessment.

How do you detect CTCs?

After enrichment, the CTCs could be detected by fluorescence (e.g. fluorescent microscope, fluorescent spectrophotometer and flow cytometry),18,19 surface-enhanced Raman scattering (SERS),20 or electrical impedance.

Why is it challenging to collect and analyze CTCs?

However, due to a limited captured number of CTCs in most cancer types, it is difficult to analyze the SNV evolutionary structure in individual patients. Moreover, copy number variation (CNV) is also frequently altered during cancer evolution.

What is a high CTC count?

N≥6 (more than 6 CTCs per 7.5 ml blood including 6) was defined as high CTC.

Why azithromycin is given for 3 days?

It is concluded that a 3-day regimen of azithromycin prescribed as tablets is as clinically and microbiologically effective as a 10-day regimen of co-amoxiclav in the treatment of acute lower respiratory tract infections.

How is a CTC test done?

Circulating Tumor Cells Assay CTC is checked at three time points –before initiation of therapy, after completion of first cycle & one year later. Defined threshold values for CTC counts for specified cancers such as Breast, Prostate, Colorectal cases, helps to assess disease status even at the baseline CTC count.

When to use CellSearch for a CTC test?

CELLSEARCH ® CTC Test results should be used in conjunction with all clinical information derived from diagnostic tests (eg, imaging, laboratory tests), physical examination, and complete medical history, in accordance with appropriate management procedures.

How does the CellSearch circulating tumor cell KIT work?

CELLSEARCH ® Circulating Tumor Cell Kit (Epithelial) Instructions for Use. Janssen Diagnostics, LLC. > How does the CELLSEARCH ® System work? The CELLSEARCH ® System uses unique technology to capture, isolate, and enumerate circulating tumor cells (CTCs) from a 7.5-mL blood sample.

When to use CellSearch for peripheral blood cancer?

The presence of CTCs in the peripheral blood, as detected by the CELLSEARCH ® CTC Test, is associated with decreased progression-free survival and decreased overall survival in patients treated for metastatic breast, colorectal, or prostate* cancer. The test is to be used as an aid in the monitoring…

When to use cellsave preservative in CTCs?

CellSave Preservative Tubes provide an optimized cell preservative that: Stabilizes circulating tumor cells (CTCs) for up to 96 hours at room temperature, which allows shipment of samples from remote locations for analysis.