What are the different grades of HPMC?

When used as release-controlling coating agents for tableted core-based pulsatile delivery systems, three different hydroxypropyl methylcellulose (HPMC) grades, Methocel E5, E50, and K4M, provided lag phases of varying duration (Methocel K4M > E50 > E5) and a prompt and quantitative model drug release.

What is K in HPMC K4M?

K means gelling temperature is between 70-90℃. The viscosity is 4000cps.

What is the molecular weight of HPMC?

1261.4
Hydroxypropylmethylcellulose

Are HPMC capsules safe?

Such is the case for HPMC hard capsules. They’re vegan, made from cellulose fiber and therefore regarded as natural. Hydroxypropyl methylcellulose (HPMC), also known as hypromellose, is produced from cellulose, a natural polymer and fiber, which is considered to be safe for human consumption.

What is K4M?

METHOCEL™ K4M is a medium molecular weight hydroxypropyl methylcellulose (HPMC) thickener. It will yield a viscosity of 4,000 cP at 2% in water and is typically used in coatings, adhesives, and ceramics.

What is HPMC used for?

HPMC is used as a raw material for coatings with moderate strength, moderate moisture and oxygen barrier properties, elasticity, transparency, and resistance to oil and fat. It is also used as a tablet binder and as a tablet matrix for extended release [178].

What is Methocel E5?

Product Overview. METHOCEL™ E5 Premium LV is a water-soluble HPMC polymer with moderate hydroxypropyl substitution and high methoxy content. This premium grade can be used in industrial applications that require pharmaceutical grade material.

Is HPMC soluble in water?

Water
Hypromellose/Soluble in

Is capsule cover harmful?

However, capsules made from gelatin carry some side effects too. They are reported to cause indigestion, upset and bloated stomach, hypersensitivity, exposure to toxins leading to gastric problems, and their excessive consumption can also cause kidney and liver damage.

What are the side effects of hypromellose?

Common side effects may include: dry eyes….Hypromellose ophthalmic side effects

• eye redness, itching, or discomfort;
• vision changes;
• puffy or droopy eyelids; or.
• a lump or swelling in your eyelid.

What is the full form of HPMC?

HPMC (H.P. Horticulture Produce Marketing & Processing Corporation, a HP State Government Undertaking) was incorporated on 10th June, 1974 with the financial assistance of World Bank.

Why is HPMC popular?

HPMC has many of the desired coating polymer properties. It provides aqueous soluble films; easy processing because of its nontacky nature; a transparent, tough, and flexible film that protects fragile tablets; improved appearance; and resistance to abrasion.

What are the different grades of aquasolve hpmcas?

Grades and Types AquaSolve HPMCAS is produced in three substitution grades: L, M and H. The three grades are insoluble in acidic aqueous solutions. All three grades are soluble in dilute caustic solution, and to various degrees in acetone and methanol. Each grade is available in fine (F) and granular (G) particle sizes.

Who was the MVP of the 2010 NFL season?

The regular season began with the NFL Kickoff game on NBC on Thursday, September 9, at the Louisiana Superdome as the New Orleans Saints, Super Bowl XLIV champions, defeated the Minnesota Vikings 14–9. Tom Brady, quarterback of the New England Patriots, was named MVP for the 2010 season.

What causes the drug release rate from HPMC matrices?

The drug release rate from HPMC matrices was influenced by the drug/HPMC ratio, drug solubility, compression force, and viscosity grade of the HPMC.

Which is hydroxypropylated cellulose ether is HPMC?

HPMC is a partly O -methylated and O-2-hydroxypropylated cellulose ether. Manufactured by reacting alkali cellulose with methyl chloride and propylene oxide, this polymer is available in various substitution ratios and MW grades. HPMC is widely used in solid dosage forms as a binder, a film coating agent, and a controlled release matrix.