How are Downey cells classified?

There are three types of Downey cells: Type I: small cells with minimum cytoplasm, indented nucleus/irregular nuclear membrane, and condensed chromatin. Type II: larger cells with abundant cytoplasm, the lymphocyte cytoplasm seem to hug the red cells. This is the most common type of Downey cells.

What is Downey cell?

[ dou′nē ] n. A type of atypical lymphocyte usually occurring in infectious mononucleosis and other viral diseases.

What does reactive Lymphs present mean?

Reactive lymphocytes are immune-stimulated lymphocytes with upregulated synthesis of inflammatory mediators, and/or immunoglobulins (antibodies), or both. Reactive lymphocytes in peripheral blood suggest active, systemic antigenic stimulation secondary to both infectious and noninfectious disorders.

What causes Downey cells?

These cells are also called Downey type II cells. They can be seen in a variety of conditions, but are often increased in infectious mononucleosis due to EBV infection.

Which disease is diagnosed by the presence of Downey cells?

In 1923, McKinlay and Downey published a description of three types of reactive or atypical lymphocytes, which they called Downey cells. The presence of many of these cells became the standard laboratory test for infectious mononucleosis.

What is the full name of mono?

About Infectious Mononucleosis. Infectious mononucleosis, also called “mono,” is a contagious disease. Epstein-Barr virus (EBV) is the most common cause of infectious mononucleosis, but other viruses can also cause this disease.

What is the difference between atypical and reactive lymphocytes?

Reactive, or atypical, lymphocytes are relatively fragile cells, and as a result can be squeezed out of shape by surrounding cells, giving them a scalloped appearance instead of a smooth cytoplasmic edge. The nucleus of the reactive lymphocyte is larger than that of the small lymphocyte, and is more irregular in shape.

What are the symptoms of lymphocytosis?

Signs and Symptoms of Chronic Lymphocytic Leukemia

• Weakness.
• Feeling tired.
• Weight loss.
• Chills.
• Fever.
• Night sweats.
• Swollen lymph nodes (often felt as lumps under the skin)
• Pain or a sense of “fullness” in the belly (this can make someone feel full after only a small meal), which is caused by an enlarged spleen and/or liver.

What are Downey McKinlay cells?

Why do I have atypical lymphocytes?

A large number of atypical lymphocytes are often found in viral infections like mononucleosis, cytomegalovirus infections and hepatitis B. Toxoplasmosis, certain bacterial infections, medications, stress and autoimmune diseases can also be accompanied by a larger number of atypical lymphocytes.