What is CD117 a marker for?

C c-kit. c-kit (also called CD117) is a type III receptor tyrosine kinase expressed predominantly in bone marrow stem/progenitor cells118 and has recently been identified as a marker for EPC and cardiac progenitor cell identity.

What does positive for CD117 mean?

It binds to a substance called stem cell factor (SCF), which causes certain types of blood cells to grow. CD117 may also be found in higher than normal amounts, or in a changed form, on some types of cancer cells, including gastrointestinal stromal tumors and melanoma.

Where does CD117 show up in a gist?

CD117 was almost always (85%) expressed in both benign and malignant GISTs. CD117 was observed both in the spindle cell and epithelioid subtypes of GISTs in all locations. In addition to reacting with the CD34-positive GISTs, CD117 was positive in some CD34-negative cases. Approximately one-third of GISTs coexpressed CD117 and smooth muscle actins.

Which is more sensitive CD34 or CD117 stromal tumors?

CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34 Gastrointestinal stromal tumors (GISTs) represent a distinct and the most important subset of mesenchymal tumors of the GI tract.

Is there a correlation between CD117 and DOG-1?

A total of 94/99 (94%) GISTs stained positive for CD117, 81/99 (82%) for PKCθ and 90/99 (91%) for DOG-1. A significant correlation was noted between CD117 and DOG-1 expression ( p = 0.0001). All three markers were expressed in 74% (73/99) of GISTs.

Which is the most common marker for gastrointestinal stromal tumors?

Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKCθ expression. Is there any advantage in using several markers? Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract.