Can diltiazem be compounded?

Diltiazem is used in dogs to treat hypertension and SVTs. This is a compounded medication specifically made for your pet based on a prescription from your licensed veterinarian. Compounded medications are not returnable.

How do you prescribe diltiazem ointment?

The Diltiazem/Nifedipine ointment should be applied 3 times per day, or as directed. A pea-sized drop should be placed on the tip of your finger and then gently placed inside the anus. The finger should be inserted 1/3 – 1/2 its length and may be covered with a plastic glove or finger cot.

How do you make nifedipine ointment?

Topical nifedipine ointment regimen was prepared by a pharmacist diluting 100 mg of nifedipine in 20 g of yellow soft paraffin to produce a preparation of 0.5%. Patients were instructed to apply the ointment circumferentially 1 cm inside the anus, near the internal anal sphincter, every 8 h for 8 wk.

How do you apply topical diltiazem?

Apply a small amount to your finger (approximately 2.5cm) and place the cream just inside the anus, at the entrance. A finger covering, such as cling film or a disposable glove may be used to apply the ointment. Use the cream twice a day every day (morning and evening) for 2 months.

Is diltiazem good for hemorrhoids?

Diltiazem ointment (Cardizem) is a calcium channel class of medication we use to help heal anal fissures, promote wound healing, or treat external thrombosed hemorrhoids.

Is diltiazem cream over the counter?

There no commercially manufactured formulation of topical 2% diltiazem has been approved yet by the Food and Drug Administration for the treatment of anal fissure, prescriptions for the medication need to be compounded with a prescription from a doctor. Consult your prescriber.

How quickly does diltiazem ointment work?

In keeping with earlier reports[11-13], topical 2% diltiazem gel in this study provided earlier pain relief, with a significant reduction in pain after 1 wk and preceded the significant healing rate of chronic anal fissure observed at 6 wk of treatment.

Is lidocaine good for fissures?

At the end of six weeks, healing of anal fissures occurred in 94.5 percent of patients treated with nifedipine/lidocaine gel compared with 16.4 percent of patients receiving lidocaine/hydrocortisone gel (P < 0.001; number needed to treat: 1.3).

Is it better to take diltiazem in the morning or at night?

Because of the increased risk of myocardial ischemia in the morning hours, it has been suggested that the administration of anti-ischemic medication before bedtime may be more effective than the traditional morning dosing.

What can you not take with diltiazem?

Common medications that may interact with diltiazem include:

• anticonvulsants, such as fosphenytoin.
• antifungal agents, such as itraconazole.
• alfentanil.
• amiodarone.
• beta-blockers, such as atenolol, labetalol, or metoprolol.
• buspirone.
• benzodiazepines such as midazolam or triazolam.
• carbamazepine.

Is diltiazem better than nitroglycerin?

Conclusions: Smooth muscle relaxant drugs do not achieve a higher cure rate than the traditional measures used in CAF, but offer more symptomatic relief, providing an opportunity to avoid surgery. Topical diltiazem does not have the side effects of the nitroglycerin and is better accepted by patients.

Is it OK to compound 2% diltiazem ointment?

This grittiness can be uncomfortable in the application area; it can also interfere with the absorption of the ointment into the rectal tissue. When compounding the 2% Diltiazem ointment, it is important to run the ointment thru an ointment mill to reduce the particle size and lessen the grittiness of the final product.

What can diltiazem hydrochloride be used for?

Diltiazem hydrochloride, a calcium channel blocker, can be used for treating anal fissures by lowering anal sphincter pressure (smooth muscle around the rectum), and also promotes wound healing and treat external thrombosed hemorrhoids.

How long does it take diltiazem ointment to heal?

Depending on the severity of the anal fissure, it may take several weeks of treatment for the fissure to heal. Patients should continue using diltiazem-ointment for the entire prescribed treatment period, which can be up to 3 months or more as directed.

Where can I get diltiazem for a fissure?

It is only available at compounding pharmacies. For fissures the ointment should be applied three times a day usually for six weeks and then one to two times a day for usually an additional six weeks. A pea size drop should be placed on the tip of your index finger and then the ointment is gently placed inside of the rectum.