Can I donate plasma if I have HLA antibodies?

Your HLA antibodies pose absolutely no risk to you. You will remain eligible to donate red blood cells. Unfortunately, you will no longer be eligible to donate plasma or plasma blood products, such as platelets collected by apheresis.

What does it mean if you have HLA antibodies?

This test checks your blood for antibodies against a cell marker called a human leukocyte antigen (HLA). The test is done if you need an organ transplant, to help find a donor organ that will work in your body. Different forms of the HLA antibody are involved in autoimmune diseases.

Who needs HLA platelets?

HLA-matched platelets are indicated for patients that have thrombocytopenia and have demonstrated CCI values consistent with immune refractory thrombocytopenia on at least two occasions.

Do they test for antibodies when you donate platelets?

COVID-19 Antibody Testing Has Ended If you donated blood, platelets or plasma between June 15, 2020 and June 25, 2021 the results of your previous antibody test(s) are available by logging in to your Blood Donor account on the Blood Donor App or online.

Do I lose my antibodies if I donate plasma?

When I donate plasma do I lose all my antibodies that help my own immunity? Much like regular blood and plasma donation, only some of the circulating antibodies are collected from COVID convalescent plasma (CCP) donation. The vast majority of cells which make antibodies are maintained by the donor.

How common is it to have HLA antibodies?

The prevalence of any HLA antibody was similar in non-transfused (n=1138) and transfused (n=895) men, 1.0 vs. 1.7% (p=0.16). HLA antibodies were detected in 17.3% of all female donors (n=5834) and in 24.4 % of those with a history of previous pregnancy (n=3992).

What is HLA in your blood?

Human leukocyte antigens (HLA) are specialized proteins present on the surface of all cells in the body except red blood cells. The HLA genes that individuals inherit are responsible for the HLA antigens present on their cells.

How common are HLA antibodies?

Do platelets have HLA?

Human Leukocyte antigens (HLA) are proteins that are found on most cells in your body including platelets.

Do I lose antibodies if I donate plasma?

Can a platelet donor be tested for HLA?

In addition, we modified our Medical History Questionnaire to ask female donors whether they have been pregnant since their last donation. Platelet donors who respond yes will be screened for HLA antibodies. We will also retest platelet donors after any subsequent pregnancies.

What kind of antibodies are in platelet donations?

The antibodies are present in plasma — and platelet donations contain a high volume of plasma, so our current efforts are directed at screening blood samples from female platelet donors to test for the HLA antibody.

Can a platelet donor be tested for TRALI?

New HLA Antibody Testing Policy for Female Platelet Donors. TRALI is a rare but serious complication of blood transfusions most commonly thought to be caused by a reaction to white blood cell antibodies present in the donor’s plasma. When transfused, these antibodies can sometimes cause plasma to leak into the patient’s lungs,…

Do you have to be screened for HLA antibodies?

Platelet donors who respond yes to that question will be screened for HLA antibodies. Platelet donors will also be retested after every subsequent pregnancy. These adjustments are being made as part of our effort to reduce occurrences of Transfusion-Related Acute Lung Injury (TRALI).